ArticleThe Journal of investigative dermatology2013
Endogenous retinoids in the pathogenesis of alopecia areata.
Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition.Communications biology · 2024Article
- Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices.Science (New York, N.Y.) · 2024Article
- Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia.Medicina (Kaunas, Lithuania) · 2023Article
- Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study.Health science reports · 2023Article
- Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms.Precision clinical medicine · 2023Article
- Granzyme B in Autoimmune Skin Disease.Biomolecules · 2023Review
- Differential impact of environmental factors on systemic and localized autoimmunity.Frontiers in immunology · 2023Review
- Vitamin A in Skin and Hair: An Update.Nutrients · 2022Review
- An overview of the genetic aspects of hair loss and its connection with nutrition.Journal of preventive medicine and hygiene · 2022Review
- Comprehensive Assessment of Skin Disorders in Patients with Common Variable Immunodeficiency (CVID).Journal of clinical immunology · 2022Article
- Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin.Nutrition research (New York, N.Y.) · 2021Article
- Dietary Habits in Japanese Patients with Alopecia Areata.Clinical, cosmetic and investigational dermatology · 2021Article
- Dietary Vitamin A Impacts Refractory Telogen.Frontiers in cell and developmental biology · 2021Article
- Post-natal all-trans-retinoic acid biosynthesis.Methods in enzymology · 2020Article
- The Role of Micronutrients in Alopecia Areata: A Review.American journal of clinical dermatology · 2017Review
- Treatment of alopecia universalis with oral alitretinoin: A case report.JAAD case reports · 2017Article
- Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Autoimmunity reviews · 2016Review
- Dermal lymphatic dilation in a mouse model of alopecia areata.Experimental and molecular pathology · 2016Article
- Alcohol exposure in utero perturbs retinoid homeostasis in adult rats.Hepatobiliary surgery and nutrition · 2015Article
- Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle.Experimental biology and medicine (Maywood, N.J.) · 2015Article
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Alopecia areata (AA) is an autoimmune disease that attacks anagen hair follicles. Gene array in graft-induced C3H/HeJ mice revealed that genes involved in retinoic acid (RA) synthesis were increased, whereas RA degradation genes were decreased in AA compared with sham controls. This was confirmed by immunohistochemistry in biopsies from patients with AA and both mouse and rat AA models. RA levels were also increased in C3H/HeJ mice with AA. C3H/HeJ mice were fed a purified diet containing one of the four levels of dietary vitamin A or an unpurified diet 2 weeks before grafting and disease progression followed. High vitamin A accelerated AA, whereas mice that were not fed vitamin A had more severe disease by the end of the study. More hair follicles were in anagen in mice fed high vitamin A. Both the number and localization of granzyme B-positive cells were altered by vitamin A. IFNγ was also the lowest and IL13 highest in mice fed high vitamin A. Other cytokines were reduced and chemokines increased as the disease progressed, but no additional effects of vitamin A were seen. Combined, these results suggest that vitamin A regulates both the hair cycle and immune response to alter the progression of AA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.