ArticleAmerican journal of human genetics1990
Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.
Article in American journal of human genetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 91 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide linkage studies across autoimmune diseases.European journal of human genetics : EJHG · 2009Pooled it
- Heterogeneity-based genome search meta-analysis for preeclampsia.Human genetics · 2006Pooled it
- Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches.Journal of human genetics · 2006Pooled it
- Sex-Dependent Aggregation of Tinnitus in Swedish Families.Journal of clinical medicine · 2020Article
- A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.PLoS genetics · 2017Article
- 2015 Curt Stern Award.American journal of human genetics · 2016Article
- The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CDKAL1, JAZF1, and IGF1 genes.Omics : a journal of integrative biology · 2015Article
- Quality of family history collection with use of a patient facing family history assessment tool.BMC family practice · 2014Article
- Article
- Type 2 Diabetes Genetics: Beyond GWAS.Journal of diabetes & metabolism · 2012Article
- Study designs for identification of rare disease variants in complex diseases: the utility of family-based designs.Genetics · 2011Article
- A twin approach to unraveling epigenetics.Trends in genetics : TIG · 2011Review
- Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD.Attention deficit and hyperactivity disorders · 2010Review
- High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.PloS one · 2010Article
- Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings.Human heredity · 2010Article
- Bayesian intervals for linkage locations.Genetic epidemiology · 2009Article
- Human genetics of infectious diseases: between proof of principle and paradigm.The Journal of clinical investigation · 2009Review
- Genome-wide study of families with absolute pitch reveals linkage to 8q24.21 and locus heterogeneity.American journal of human genetics · 2009Article
- Candidate genes for cannabis use disorders: findings, challenges and directions.Addiction (Abingdon, England) · 2009Review
- Genotype-specific recurrence risks as indicators of the genetic architecture of complex diseases.American journal of human genetics · 2008Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
The results from the second paper of this series are reexamined for markers that are not completely polymorphic. A maximum lod score (MLS) criterion is defined for affected relative pairs. The expected MLS (EMLS) is calculated as a function of the marker polymorphic information content (PIC) for various values of lambda R (relative risk ratio) and different relative types by using simulations. An m-allele model with equal allele frequencies is employed. The EMLS is calculated for two sampling strategies: scheme 1, which uses pairs only, and scheme 2, which also includes additional informative relatives. For scheme 2, the percent of the maximum achievable EMLS (i.e., for a marker with a PIC of 1.0) is approximately equal to the marker PIC value for all relative types. For scheme 1, the EMLS is greatly diminished unless PIC is high, especially for distant relatives. For example, scheme 1 is not cost-effective for sibs unless PIC greater than .7; for second- and third-degree relatives, PIC must be greater than .85. Therefore, in general, it will be worthwhile to type additional relatives in linkage studies using affected pairs. The comparative value of sibs versus distant relatives depends on lambda R, recombination theta, and PIC. For large lambda R and PIC values, distant relatives are preferred. Alternatively, for smaller lambda R and PIC values, sibs are best.
Indexed as
Identifiers
2301394PMC1684966What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.