ArticleJournal of endocrinological investigation2013
Seasonal variations of plasma gonadotropin, prolactin, and testosterone levels in primary and secondary hypogonadism: evidence for an independent testicular role.
Article in Journal of endocrinological investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Chrono-Endocrinology in Clinical Practice: A Journey from Pathophysiological to Therapeutic Aspects.Life (Basel, Switzerland) · 2024Review
- Changes of bone turnover markers and testosterone in Japanese male endurance runners: a pilot study.Journal of bone and mineral metabolism · 2023Article
- Global warming and testis function: A challenging crosstalk in an equally challenging environmental scenario.Frontiers in cell and developmental biology · 2022Review
- Association between meteorological variables and semen quality: a retrospective study.International journal of biometeorology · 2021Article
- Hormonal Changes in High-Level Aerobic Male Athletes during a Sports Season.International journal of environmental research and public health · 2020Article
- Endocrine rhythms and sport: it is time to take time into account.Journal of endocrinological investigation · 2019Review
- How much does obesity affect the male reproductive function?International journal of obesity supplements · 2019Review
- Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years.Frontiers in endocrinology · 2019Article
- Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations?Oncotarget · 2017Article
- Vitamin D levels and bone mineral density: are LH levels involved in the pathogenesis of bone impairment in hypogonadal men?Journal of endocrinological investigation · 2014Observational
- Opposite influence of light and blindness on pituitary-gonadal function.Frontiers in endocrinology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeasonal hormonal rhythmicity of the hypothalamic-pituitary-gonadal axis may influence reproductive and sexual activity in mammals.
aimTo investigate whether pituitary-gonadal axis secretion seasonality occurs in men with primary and secondary hypogonadism and whether a hierarchical machinery regulates these variations. SUBJECTS AND
methodsSix adult males with Klinefelter's syndrome (KS), eight with idiopathic normosmic hypogonadotropic hypogonadism (HH) and ten sex- and age-matched healthy controls were studied longitudinally for one year. Every three months, three plasma samples for assay of testosterone, LH, FSH, and prolactin were drawn and the mean value was used for statistical analysis.
resultsHealthy males showed a significant seasonality in LH (zenith in spring) and testosterone (zenith in autumn) but not in FSH and prolactin concentrations. Patients with KS and those with HH showed a seasonal rhythmicity only of testosterone values, even if with small amplitude, with the zenith in spring and summer respectively.
conclusionThe lack of dependence of testosterone on gonadotropin variations in normal men and the persistence of seasonal testosterone but not gonadotropin variations both in primary and secondary hypogonadism seem to indicate a possible independent testicular regulation of this seasonality. The shift of testosterone peak in hypogonadal men with respect to controls suggests that LH variations could play a synchronizing, rather than pace-making, role in seasonal testosterone variations. Since hormonal seasonality may also influence gonadal activity in humans, replacement therapy in hypogonadism should be aimed also at restoring a normal seasonal rhythmicity of pituitary-gonadal hormone concentrations.
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