ArticleAmerican journal of human genetics1990
Linkage strategies for genetically complex traits. II. The power of affected relative pairs.
Article in American journal of human genetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
212 citing papers in PubMed, 1 synthesis or guideline pooled it, 871 citations in OpenAlex.
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- A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.American journal of human genetics · 2019Article
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- Clinical utility of a Web-enabled risk-assessment and clinical decision support program.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Determinants of Power in Gene-Based Burden Testing for Monogenic Disorders.American journal of human genetics · 2016Article
- Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics.Current diabetes reports · 2016Review
- 2015 Curt Stern Award.American journal of human genetics · 2016Article
- The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage.Frontiers in public health · 2016Article
- Epidemiology and genetics of hypodontia and microdontia: a study of twin families.The Angle orthodontist · 2015Article
- Human genetics of diabetic retinopathy.Journal of endocrinological investigation · 2014Review
- Quality of family history collection with use of a patient facing family history assessment tool.BMC family practice · 2014Article
- Evaluating empirical bounds on complex disease genetic architecture.Nature genetics · 2013Article
152 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The power to detect disease-susceptibility loci through linkage analysis using pairs of affected relatives and affected-unaffected pairs is examined. Allelic identity by descent (ibd) for a completely polymorphic marker for sibling, uncle-nephew, grandparent-grandchild, half-sib, and first-cousin pairs is considered. Affected-unaffected pairs generally represent a poor strategy. For single-locus models, ibd depends on lambda R, the risk ratio for type R relatives compared with population prevalence, and the recombination fraction theta. The ibd for grandparent-grandchild pairs is least affected by recombination, followed by sibs, half-sib, uncle-nephew, and first-cousin pairs. For diseases with large lambda values and for small theta values, distant relatives offer greater power. For larger theta values, grandparent-grandchild pairs are best; for small lambda values, sibs are best. Additive and multiplicative multilocus models are considered. For the multiplicative model, the same formulas as in the single-locus model apply, except that lambda iR (for the ith contributing locus) is substituted for lambda R. For the additive model, the deviation from null expectation for ibd is divided among all contributing loci. Compared with the multiplicative model, for an additive model there is usually greater advantage in distant relationships. Multipoint analysis using linked marker loci for affected relative pairs is described. Simultaneous use of multiple markers diminishes the effect of recombination and allows for localization of the disease-susceptibility locus.
Indexed as
Identifiers
2301393PMC1684989W1641197739What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.