ArticleAmerican journal of human genetics1990
Linkage strategies for genetically complex traits. I. Multilocus models.
Article in American journal of human genetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 369 papers, 3 of them syntheses that pooled it.
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Who cites it
369 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,321 citations in OpenAlex.
- Power considerations for λ inflation factor in meta-analyses of genome-wide association studies.Genetics research · 2016Pooled it
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
- New genes associated with schizophrenia in neurite formation: a review of cell culture experiments.Molecular psychiatry · 2007Pooled it
- Genomewide association for schizophrenia in the CATIE study: results of stage 1.Molecular psychiatry · 2008Trial
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- Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank.Genetic epidemiology · 2025Article
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- Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study.Cardiovascular diabetology · 2023Article
- Theoretical Framework for the Study of Genetic Diseases Caused by Dominant Alleles.Life (Basel, Switzerland) · 2023Article
- Genetic and modifiable risk factors combine multiplicatively in common disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Analysis of Familial Aggregation Using Recurrence Risk for Complex Survey Data.Biostatistics & epidemiology · 2023Article
- Genetic heterogeneity: Challenges, impacts, and methods through an associative lens.Genetic epidemiology · 2022Review
- How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia.Genes · 2022Article
- Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes.Genes & nutrition · 2021Article
309 more citing papers are in PubMed but not listed here.
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Abstract
In order to investigate linkage detection strategies for genetically complex traits, multilocus models of inheritance need to be specified. Here, two types of multilocus model are described: (1) a multiplicative model, representing epistasis (interaction) among loci, and (2) an additive model, which is shown to closely approximate genetic heterogeneity, which is characterized by no interlocus interaction. A ratio lambda R of risk for type R relatives that is compared with population prevalence is defined. For a single-locus model, lambda R - 1 decreases by a factor of two with each degree of relationship. The same holds true for an additive multilocus model. For a multiplicative (epistasis) model, lambda R - 1 decreases more rapidly than by a factor of two with degree of relationship. Examination of lambda R values for various classes of relatives can potentially suggest the presence of multiple loci and epistasis. For example, data for schizophrenia suggest multiple loci in interaction. It is shown in the second paper of this series that lambda R is the critical parameter in determining power to detect linkage by using affected relative pairs.
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2301392PMC1684987W48750798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.