ArticleJournal of occupational medicine and toxicology (London, England)2012
Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach.
Article in Journal of occupational medicine and toxicology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Identifying risk factors for COPD and adult-onset asthma: an umbrella review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Is Isocyanate Exposure and Occupational Asthma Still a Major Occupational Health Concern? Systematic Literature Review.International journal of environmental research and public health · 2021Pooled it
- Exposure to formaldehyde and asthma outcomes: A systematic review, meta-analysis, and economic assessment.PloS one · 2021Pooled it
- Work-Related Asthma From Exposure to Cardboard and Paper Products.American journal of industrial medicine · 2026Article
- Silent invaders: the role of MPs on epithelium inflammation and damage in airway diseases.Frontiers in allergy · 2026Review
- A TRPA1-mediated substance P release assay as anFrontiers in toxicology · 2026Article
- Impact of occupational exposures in patients with chronic obstructive pulmonary disease: current understanding and knowledge gaps.Current opinion in pulmonary medicine · 2025Review
- Formaldehyde and asthma: a plausibility?Archives of toxicology · 2025Review
- Occupational exposure and new-onset asthma in the population-based Telemark study: a 5-year follow-up.BMJ open · 2024Article
- Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors.Archives of toxicology · 2024Review
- Occupational respiratory disorders in Iran: a review of prevalence and inducers.Frontiers in medicine · 2024Review
- Engineered Stone Fabrication Work Releases Volatile Organic Compounds Classified as Lung Irritants.Annals of work exposures and health · 2023Article
- Environmental Substances Associated with Chronic Obstructive Pulmonary Disease-A Scoping Review.International journal of environmental research and public health · 2022Article
- The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases.International journal of environmental research and public health · 2022Review
- Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review.Journal of applied toxicology : JAT · 2022Review
- Occupations and exposure events in acute and subacute irritant-induced asthma.Occupational and environmental medicine · 2021Article
- Occupation and subcategories of asthma: a population-based incident case-control study.Occupational and environmental medicine · 2021Article
- Challenges in Diagnosing Occupational Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2021Review
- Reviews in environmental health: How systematic are they?Environment international · 2021Article
- Inhalation Challenge Tests in Occupational Asthma: Why Are Multiple Tests Needed?Turkish thoracic journal · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundRespiratory irritants represent a major cause of occupational obstructive airway diseases. We provide an overview of the evidence related to irritative agents causing occupational asthma or occupational COPD.
methodsWe searched MEDLINE via PubMed. Reference lists of relevant reviews were also screened. The SIGN grading system was used to rate the quality of each study. The modified RCGP three-star system was used to grade the body of evidence for each irritant agent regarding its causative role in either occupational asthma or occupational COPD.
resultsA total of 474 relevant papers were identified, covering 188 individual agents, professions or work-sites. The focus of most of the studies and the predominant diagnosis was occupational asthma, whereas occupational COPD arose only incidentally.The highest level assigned using the SIGN grading was 2+ (well-conducted systematic review, cohort or case-control study with a low risk of confounding or bias). According to the modified RCGP three-star grading, the strongest evidence of association with an individual agent, profession or work-site ("**") was found for 17 agents or work-sites, including benzene-1,2,4-tricarboxylicacid-1,2-anhydride, chlorine, platinum salt, isocyanates, cement dust, grain dust, animal farming, environmental tobacco smoke, welding fumes or construction work. Phthalic anhydride, glutaraldehyde, sulphur dioxide, cotton dust, cleaning agents, potrooms, farming (various), foundries were found to be moderately associated with occupational asthma or occupational COPD ("*[+]").
conclusionThis study let us assume that irritant-induced occupational asthma and especially occupational COPD are considerably underreported. Defining the evidence of the many additional occupational irritants for causing airway disorders will be the subject of continued studies with implications for diagnostics and preventive measures.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.