ArticleCell death & disease2012
TP53 PIN3 and PEX4 polymorphisms and infertility associated with endometriosis or with post-in vitro fertilization implantation failure.
Article in Cell death & disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Double jeopardy: howFrontiers in cell and developmental biology · 2026Review
- From bench to in silico and backwards: What have we done on genetics of recurrent pregnancy loss and implantation failure and where should we go next?Genetics and molecular biology · 2024Article
- Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes.Journal of assisted reproduction and genetics · 2021Article
- Effects of Diluent pH on Enrichment and Performance of Dairy Goat X/Y Sperm.Frontiers in cell and developmental biology · 2021Article
- Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women.Journal of biomedical science · 2019Article
- Evaluation of clinical utility of P53 gene variations in repeated implantation failure.Molecular biology reports · 2019Article
- Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles.International journal of reproductive biomedicine · 2018Article
- Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle.PloS one · 2017Article
- Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome.PloS one · 2016Article
- Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.PloS one · 2015Article
- A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.BMC cancer · 2014Article
- Article
- Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss.Journal of assisted reproduction and genetics · 2014Article
- Molecular dynamics of the full-length p53 monomer.Cell cycle (Georgetown, Tex.) · 2013Article
- Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy.Cell death & disease · 2013Article
- ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure.Disease markers · 2013Article
- The impact of endometriosis on IVF/ICSI outcomes.International journal of clinical and experimental pathology · 2013Article
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis.Human reproduction updateReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 has a crucial role in human fertility by regulating the expression of leukemia inhibitory factor (LIF), a secreted cytokine critical for blastocyst implantation. To examine whether TP53 polymorphisms may be involved with in vitro fertilization (IVF) failure and endometriosis (END), we have assessed the associations between TP53 polymorphism in intron 2 (PIN2; G/C, intron 2), PIN3 (one (N, non-duplicated) or two (D, duplicated) repeats of a 16-bp motif, intron 3) and polymorphism in exon 4 (PEX4; C/G, p.P72R, exon 4) in 98 women with END and 115 women with post-IVF failure. In addition, 134 fertile women and 300 women unselected with respect to fertility-related features were assessed. TP53 polymorphisms and haplotypes were identified by amplification refractory mutation system polymerase chain reaction. TP53 PIN3 and PEX4 were associated with both END (P=0.042 and P=0.007, respectively) and IVF (P=0.004 and P=0.009, respectively) when compared with women both selected and unselected for fertility-related features. Haplotypes D-C and N-C were related to higher risk for END (P=0.002, P=0.001, respectively) and failure of IVF (P=0.018 and P=0.002, respectively) when compared with the Fertile group. These results support that specific TP53 haplotypes are associated with an increased risk of END-associated infertility and with post-IVF failure.
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