ArticleBMC nephrology2012
High creatinine clearance in critically ill patients with community-acquired acute infectious meningitis.
Article in BMC nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07410624 (Augmented Renal Clearance in Neurocritical Care Population), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Augmented Renal Clearance in Neurocritical Care Population: A Prospective Multicenter Study
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram.Antimicrobial agents and chemotherapy · 2019Trial
- Prospective evaluation of individualized vancomycin dosing based on a population pharmacokinetic model in patients with severe Gram-positive bacterial infection.Frontiers in pharmacology · 2026Article
- Examining the association of elevated initial serum lactate with mortality and morbidity in trauma patients: a retrospective study.International journal of emergency medicine · 2024Article
- Augmented renal clearance in neurocritical patients: An epidemiological investigation and risk-factor analysis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Burden and Risk Factors of Contrast-Associated Acute Kidney Injury in Hospitalized Zambian Children: A Prospective Cohort Study at the University Teaching Hospitals.Canadian journal of kidney health and disease · 2023Article
- Prevalence and Risk Factors of Augmented Renal Clearance: A Systematic Review and Meta-Analysis.Pharmaceutics · 2022Review
- Risk Factors Associated With Prolonged Antibiotic Use in Pediatric Bacterial Meningitis.Frontiers in pharmacology · 2022Article
- Augmented Renal Clearance in Severe Infections-An Important Consideration in Vancomycin Dosing: A Narrative Review.Frontiers in pharmacology · 2022Review
- Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To OptimizeAntimicrobial agents and chemotherapy · 2019Article
- Augmented renal clearance.Translational and clinical pharmacology · 2018Review
- Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study.Pediatric nephrology (Berlin, Germany) · 2016Observational
- Screening of patients with augmented renal clearance in ICU: taking into account the CKD-EPI equation, the age, and the cause of admission.Annals of intensive care · 2015Article
- Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?Critical care (London, England) · 2015Article
- Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.Critical care (London, England) · 2014Observational
- Clinical implications of antibiotic pharmacokinetic principles in the critically ill.Intensive care medicine · 2013Review
- Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges.Critical care (London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high dose of anti-infective agents is recommended when treating infectious meningitis. High creatinine clearance (CrCl) may affect the pharmacokinetic / pharmacodynamic relationships of anti-infective drugs eliminated by the kidneys. We recorded the incidence of high CrCl in intensive care unit (ICU) patients admitted with meningitis and assessed the diagnostic accuracy of two common methods used to identify high CrCl.
methodsObservational study performed in consecutive patients admitted with community-acquired acute infectious meningitis (defined by >7 white blood cells/mm3 in cerebral spinal fluid) between January 2006 and December 2009 to one medical ICU. During the first 7 days following ICU admission, CrCl was measured from 24-hr urine samples (24-hr-UV/P creatinine) and estimated according to Cockcroft-Gault formula and the simplified Modification of Diet in Renal Disease (MDRD) equation. High CrCl was defined as CrCl >140 ml/min/1.73 m2 by 24-hr-UV/P creatinine. Diagnostic accuracy was performed with ROC curves analysis.
resultsThirty two patients were included. High CrCl was present in 8 patients (25%) on ICU admission and in 15 patients (47%) during the first 7 ICU days for a median duration of 3 (1-4) days. For the Cockcroft-Gault formula, the best threshold to predict high CrCl was 101 ml/min/1.73 m2 (sensitivity: 0.96, specificity: 0.75, AUC = 0.90 ± 0.03) with a negative likelihood ratio of 0.06. For the simplified MDRD equation, the best threshold to predict high CrCl was 108 ml/min/1.73 m2 (sensitivity: 0.91, specificity: 0.80, AUC = 0.88 ± 0.03) with a negative likelihood ratio of 0.11. There was no difference between the estimated methods in the diagnostic accuracy of identifying high CrCl (p = 0.30).
conclusionsHigh CrCl is frequently observed in ICU patients admitted with community-acquired acute infectious meningitis. The estimated methods of CrCl could be used as a screening tool to identify high CrCl.
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