Trial reportBMC medical genetics2012
Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children.
Trial report in BMC medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.European journal of epidemiology · 2024Pooled it
- Mendelian randomisation approaches to the study of prenatal exposures: A systematic review.Paediatric and perinatal epidemiology · 2021Pooled it
- The landscape of pregnancy and prepregnancy cohorts: a scoping review.BMC pregnancy and childbirth · 2025Article
- Comparison of Neurodevelopmental Status in Early Infancy of Infants of Women With and Without Gestational Diabetes Mellitus.Indian journal of pediatrics · 2023Article
- Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children.Communications biology · 2022Article
- Estimation of Parental Effects Using Polygenic Scores.Behavior genetics · 2021Article
- Pre-conceptional Maternal Vitamin B12 Supplementation Improves Offspring Neurodevelopment at 2 Years of Age: PRIYA Trial.Frontiers in pediatrics · 2021Article
- Observational
- Data relating to prenatal lead exposure and child IQ at 4 and 8 years old in the Avon Longitudinal Study of Parents and Children.Neurotoxicology · 2017Article
- Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study.Human molecular genetics · 2017Article
- Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece.European child & adolescent psychiatry · 2017Article
- Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them.Wellcome open research · 2017Article
- Long-term health outcomes in offspring born to women with diabetes in pregnancy.Current diabetes reports · 2014Review
- Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.Diabetologia · 2014Article
- Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundIn observational epidemiological studies type 2 diabetes (T2D) and both low and high plasma concentrations of fasting glucose have been found to be associated with lower cognitive performance. These associations could be explained by confounding.
methodsIn this study we looked at the association between genetic variants, known to be robustly associated with fasting glucose and T2D risk, in the mother and her offspring to determine whether there is likely to be a causal link between early life exposure to glucose and child's intelligence quotient (IQ) scores in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. We generated a fasting glucose (FGGRS) and a T2D (T2DGRS) genetic risk score and used them in a Mendelian randomization approach.
resultsWe found a strong correlation between the FGGRS and fasting glucose plasma measurements that were available for a subset of children, but no association of either the maternal or the offspring FGGRS with child's IQ was observed. In contrast, the maternal T2DGRS was positively associated with offspring IQ.
conclusionsMaternal and offspring genetic variants which are associated with glucose levels are not associated with offspring IQ, suggesting that there is unlikely to be a causal link between glucose exposure in utero and IQ in childhood. Further exploration in even larger cohorts is required to exclude the possibility that our null findings were due to a lack of statistical power.
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Registered trials
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