ArticleProceedings of the National Academy of Sciences of the United States of America2012
Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications.Animal models and experimental medicine · 2026Review
- Emergency granulopoiesis and innate immune memory in inflammatory bowel disease.Trends in immunology · 2026Review
- Red Ginseng Ethanolic Extract Alleviates DSS-Induced Colitis in Mice by Suppressing Inflammatory Mediator Production.International journal of molecular sciences · 2026Article
- Improved efficacy and long-term protective effects of CXCR4/IL10 bioengineered mesenchymal stromal cells in a model of inflammatory bowel disease.Bioengineering & translational medicine · 2026Article
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- Ethanolic Extract of Kinkeliba (International journal of molecular sciences · 2025Article
- Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.Scientific reports · 2022Article
- Intestinal Inflammation Promotes MDL-1Cellular and molecular gastroenterology and hepatology · 2022Article
- COVID-19 and gut immunomodulation.World journal of gastroenterology · 2021Review
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- Mechanisms Underlying Bone Loss Associated with Gut Inflammation.International journal of molecular sciences · 2019Review
- Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine.Nature communications · 2019Article
- Article
- Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes.Theranostics · 2019Article
- ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.Nature communications · 2018Article
- Advances in Probiotic Regulation of Bone and Mineral Metabolism.Calcified tissue international · 2018Review
- Origin, Differentiation, and Function of Intestinal Macrophages.Frontiers in immunology · 2018Review
- Immunology of Gut-Bone Signaling.Advances in experimental medicine and biology · 2017Article
- Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.Experimental gerontology · 2015Article
- L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.Infection and immunity · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bone marrow (BM) is a large, highly active, and responsive tissue. Interestingly, little is known about the impact of colitis on hematopoietic functions. Using dextran sodium sulfate (DSS) to induce colitis in mice, we identified significant changes in the BM. Specifically, cells of the monocytic and granulocytic lineages increased nearly 60% and 80%, respectively. This change would support and promote the large infiltration of the gut with neutrophils and monocytes that are the primary cause of inflammation and tissue damage during colitis. Conversely, the early lineages of B and T cells declined in the marrow and thymus with particularly large losses observed among pre-B and pre-T cells with heightened levels of apoptosis noted among CD4(+)CD8(+) thymocytes from DSS-treated mice. Also noteworthy was the 40% decline in cells of the erythrocytic lineages in the marrow of colitis mice, which undoubtedly contributed to the anemia observed in these mice. The peripheral blood reflected the marrow changes as demonstrated by a 2.6-fold increase in neutrophils, a 60% increase in monocytes, and a decline in the lymphocyte population. Thus, colitis changed the BM in profound ways that parallel the general outcomes of colitis including infiltration of the gut with monocytes and neutrophils, inflammation, and anemia. The data provide important understandings of the full impact of colitis that may lead to unique treatments and therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.