ArticleProceedings of the National Academy of Sciences of the United States of America2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects.bioRxiv : the preprint server for biology · 2024Article
- Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells.Cell proliferation · 2022Article
- Micro-RNAs: A safety net to protect hematopoietic stem cell self-renewal.Wiley interdisciplinary reviews. RNA · 2022Review
- Cell-Crossing Functional Network Driven by microRNA-125a Regulates Endothelial Permeability and Monocyte Trafficking in Acute Inflammation.Frontiers in immunology · 2022Article
- Review
- 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING.The EMBO journal · 2021Article
- Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia.Clinical epigenetics · 2021Article
- miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin.Blood · 2020Article
- Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells.Chemico-biological interactions · 2019Article
- MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones.Scientific reports · 2019Article
- Article
- Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation.Genome research · 2017Article
- Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma.Experimental and therapeutic medicine · 2016Article
- Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.Cell stem cell · 2016Article
- MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis.Current stem cell reports · 2016Article
- A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions.Nature communications · 2016Article
- MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.Cell death and differentiation · 2016Article
- Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.Nature medicine · 2016Article
- MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway.Oncotarget · 2015Article
- A functional screen identifies miRs that induce radioresistance in glioblastomas.Molecular cancer research : MCR · 2014Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Deregulation of microRNA (miRNA) expression can lead to cancer initiation and progression. However, limited information exists on the function of miRNAs in cancer maintenance. We examined these issues in the case of myeloproliferative diseases and neoplasms (MPN), a collection of hematopoietic neoplasms regarded as preleukemic, thereby representing early neoplastic states. We report here that microRNA-125a (miR-125a)-induced MPN display a complex manner of oncogene dependence. Following a gain-of-function genomics screen, we overexpressed candidate miR-125a in vivo, which led to phenotypes consistent with an atypical MPN characterized by leukocytosis, monocytosis, splenomegaly, and progressive anemia. The diseased MPN state could be recapitulated in a doxycycline-inducible mouse model. Upon doxycycline withdrawal, the primary MPN phenotypes rapidly resolved after the discontinuation of miR-125a overexpression. However, reinduction of miR-125a led to complex phenotypes, with some animals rapidly developing lethal anemia with extensive damages in the spleen. Forced expression of miR-125a resulted in elevated cellular tyrosine phosphorylation and hypersensitivity toward hematopoietic cytokines. Furthermore, we demonstrate that miR-125a targets multiple protein phosphatases. Our data demonstrate that miR-125a-induced MPN is addicted to its sustained overexpression, and highlight the complex nature of oncogenic miRNA dependence in an early neoplastic state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.