ReviewAntiviral therapy2013
Silymarin for HCV infection.
Review in Antiviral therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Leveraging AI and Natural Compounds: Innovative Approaches in the Diagnosis and Treatment of Hepatocellular Carcinoma.Current pharmaceutical design · 2026Review
- Clinical development and informatics analysis of natural and semi-synthetic flavonoid drugs: A critical review.Journal of advanced research · 2024Review
- A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity.Molecules (Basel, Switzerland) · 2023Review
- Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals.MedComm · 2021Review
- Antiviral activity of silymarin and baicalein against dengue virus.Scientific reports · 2021Article
- Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites.Biocatalysis and agricultural biotechnology · 2021Review
- Antiviral activity of silymarin in comparison with baicalein against EV-A71.BMC complementary medicine and therapies · 2020Article
- Dehydrojuncusol, a Natural Phenanthrene Compound Extracted fromJournal of virology · 2019Article
- Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes.Frontiers in microbiology · 2018Article
- Article
- A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.Journal of pharmaceutical and biomedical analysis · 2016Article
- Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway.PloS one · 2016Article
- Grape Seed Extract Attenuates Hepatitis C Virus Replication and Virus-Induced Inflammation.Frontiers in pharmacology · 2016Article
- Quantitative prediction and clinical evaluation of an unexplored herb-drug interaction mechanism in healthy volunteers.CPT: pharmacometrics & systems pharmacology · 2015Article
- Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action.Journal of virology · 2015Article
- Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication.Hepatology (Baltimore, Md.) · 2015Article
- Antiviral activity of silymarin against chikungunya virus.Scientific reports · 2015Article
- Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics.Liver international : official journal of the International Association for the Study of the Liver · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatoprotection in cell culture and animal models, evidence for beneficial effects in humans has been equivocal. This review will summarize the current state of knowledge on silymarin in the context of HCV infection. The information was collated from a recent workshop on silibinin in Germany.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.