ArticleEnvironmental health and preventive medicine2013
Simultaneous measurement of urinary total nicotine and cotinine as biomarkers of active and passive smoking among Japanese individuals.
Article in Environmental health and preventive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Smoking status predicts anastomotic leak after esophagectomy: a systematic review & meta-analysis.Surgical endoscopy · 2024Pooled it
- Urinary and fecal excretion of aromatic amines in pet dogs and cats from the United States.Environment international · 2022Article
- Associations of biomarkers for exposure to tobacco smoke with lung cancer risk in Korea.Cancer biomarkers : section A of Disease markers · 2022Article
- Characterization of urinary cotinine concentrations among non-smoking adults in smoking and smoke-free homes in the Korean national environmental health survey (KoNEHS) cycle 3 (2015-2017).BMC public health · 2021Article
- An innovation involving self-surveillance and serious gaming to increase smoking quit rate: Protocol for a pilot randomized controlled trial.Tobacco prevention & cessation · 2021Article
- Associations between Exposure to Tobacco Smoke and Behavioral Problems in Preschool Japanese Children.Journal of environmental and public health · 2020Article
- Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives.International journal of environmental research and public health · 2018Review
- Urine Cotinine Should Be Involved in Initial Evaluation of Tinnitus in Adolescents.Clinical and experimental otorhinolaryngology · 2018Article
- Higher hair nicotine level in children compared to mother living with smoking father in Malaysia.Environmental health and preventive medicine · 2016Article
- Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.Preventive medicine reports · 2016Article
- Secondhand smoke exposure is associated with proteinuria in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Observational
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesMeasuring urinary cotinine is a popular and established method of biologically monitoring exposure to tobacco smoke. However, the lower detection limit of cotinine often impedes the evaluation of passive (second-hand) smoking and this, together with unconverted nicotine, does not reflect actual levels of exposure. Furthermore, a portion of the Japanese population might have decreased ability to metabolize nicotine. The present study was therefore carried out to validate the simultaneous analysis of total concentrations of free nicotine and cotinine and their glucuronides to determine actual levels of voluntary and involuntary exposure to cigarette smoke.
methodsUrine samples from 118 Japanese smokers and 117 non-smokers were analyzed using gas chromatography-mass spectrometry. Voluntary and involuntary smoking status was self-reported and workplace smoking restrictions were objectively evaluated.
resultsThe integrated sum of all concentrations showed 2.2- and 2.4-fold higher total levels (free and glucuronide) of nicotine and cotinine relative to the free levels. Median (quartiles) of total nicotine and cotinine were 1635 (2222) and 3948 (3512) ng/mL in smokers, and 3.5 (5.3) and 2.8 (4.2) ng/mL in non-smokers. Concentrations of urinary nicotine were higher than those of cotinine in 21 % of smokers and in 54 % of non-smokers. Nicotine and cotinine levels were significantly associated with a smoking habit, as well as being significantly associated with the workplace and home environments of non-smokers.
conclusionsThe present method can monitor voluntary and involuntary exposure to tobacco smoke. Measuring total urinary nicotine levels might be useful for analyzing exposure to cigarette smoke among non-smokers.
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