ArticleJournal of physiology and biochemistry2013
Endurance training in mice increases the unfolded protein response induced by a high-fat diet.
Article in Journal of physiology and biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease.Sports medicine and health science · 2023Article
- Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.International journal of molecular sciences · 2022Article
- HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.Journal of physiology and biochemistry · 2022Article
- Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting.Frontiers in immunology · 2022Review
- Vitamin D supplementation associated with physical exercise promotes a tolerogenic immune environment without effect on mammary tumour growth in C57BL/6 mice.European journal of nutrition · 2021Article
- Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats.Journal of physiology and biochemistry · 2021Article
- ER-Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention.International journal of molecular sciences · 2020Review
- Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways.Mediators of inflammation · 2020Review
- Article
- PGC-1α in hepatic UPR during high-fat high-fructose diet and exercise training in mice.Physiological reports · 2018Article
- Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats.Journal of cellular and molecular medicine · 2018Article
- Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update.Frontiers in physiology · 2018Review
- Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy.Nature communications · 2017Article
- Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.Frontiers in endocrinology · 2017Article
- The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise.International journal of vascular medicine · 2017Review
- Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B.Oxidative medicine and cellular longevity · 2016Article
- Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice.European journal of nutrition · 2015Article
- Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men.PloS one · 2015Article
- Using molecular biology to maximize concurrent training.Sports medicine (Auckland, N.Z.) · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Certain conditions, such as several weeks of high-fat diet, disrupt endoplasmic reticulum (ER) homeostasis and activate an adaptive pathway referred as the unfolded protein response. When the unfolded protein response fails, the result is the development of inflammation and insulin resistance. These two pathological states are known to be improved by regular exercise training but the mechanisms remain largely undetermined. As it has recently been shown that the unfolded protein response is regulated by exercise, we hypothesised that concomitant treadmill exercise training (HFD+ex) prevents ER homeostasis disruption and its downstream consequences induced by a 6-week high-fat diet (HFD) in mice by activating the protective unfolded protein response. Several well-documented markers of the unfolded protein response were measured in the soleus and tibialis anterior muscles as well as in the liver and pancreas. In HFD mice, an increase in these markers was observed (from 2- to 15-fold, P < 0.05) in all tissues studied. The combination of HFD+ex increased the expression of several markers further, up to 100 % compared to HFD alone (P < 0.05). HFD increased inflammatory markers both in the plasma (IL-6 protein, 2.5 ± 0.52-fold; MIP-1α protein, 1.3 ± 0.13-fold; P < 0.05) and in the tissues studied, and treadmill exercise attenuated the inflammatory state induced by HFD (P < 0.05). However, treadmill exercise could not reverse HFD-induced whole body glucose intolerance, assessed by OGTT (AUC, 1.8 ± 0.29-fold, P < 0.05). In conclusion, our results show that a HFD activated the unfolded protein response in mouse tissues in vivo, and that endurance training promoted this response. We speculate that the potentiation of the unfolded protein response by endurance training may represent a positive adaptation protecting against further cellular stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.