ArticlePhysical biology2012
The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs.
Article in Physical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Memoryless chemotaxis with discrete cues.Journal of the Royal Society, Interface · 2024Article
- Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification.Hereditas · 2024Article
- Size regulation of the lateral organ initiation zone and its role in determining cotyledon number in conifers.Frontiers in plant science · 2023Article
- Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.Nature communications · 2022Article
- Article
- Modulating the bicoid gradient in space and time.Hereditas · 2021Article
- Insights into mammalian morphogen dynamics from embryonic stem cell systems.Current topics in developmental biology · 2020Review
- No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo.PloS one · 2018Article
- Cortical movement of Bicoid in early Drosophila embryos is actin- and microtubule-dependent and disagrees with the SDD diffusion model.PloS one · 2017Article
- Bicoid signal extraction with a selection of parametric and nonparametric signal processing techniques.Genomics, proteomics & bioinformatics · 2015Article
- Spatiotemporal analysis of different mechanisms for interpreting morphogen gradients.Biophysical journal · 2015Article
- Estimating binding properties of transcription factors from genome-wide binding profiles.Nucleic acids research · 2015Article
- An inside-out origin for the eukaryotic cell.BMC biology · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Precise formation of morphogen gradients is essential to the establishment of reproducible pattern in development. Mechanisms proposed for obtaining the requisite precision range from simple models with few parameters to more complex models involving many regulated quantities. The synthesis-diffusion-degradation (SDD) model is a relatively simple model explaining the formation of the Bicoid gradient in Drosophila melanogaster, in which the steady-state characteristic length of the gradient is determined solely by the rates of diffusion and degradation of the morphogen. In this work, we test the SDD model in unfertilized D. melanogaster eggs, which contain a single female pronucleus and lack the nuclear division cycles and other zygotic regulatory processes seen in fertilized eggs. Using two-photon live imaging as well as a novel method for quantitative imaging based on decorrelation of photoswitching waveforms, we find that the Bicoid gradient is longer and shallower in unfertilized eggs as compared to the gradient at the same time points in fertilized eggs. Using a means of measuring the Bicoid lifetime by conjugation to a photoconvertible fluorophore, we find that the lifetime is correspondingly longer in unfertilized eggs, providing qualitative and quantitative agreement with the predictions of the SDD model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.