ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2012
Molecular ultrasound imaging using a targeted contrast agent for assessing early tumor response to antiangiogenic therapy.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Ultrasound imaging of breast tumor perfusion and neovascular morphology.Ultrasound in medicine & biology · 2015Trial
- Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Application of Ultrasound Combined with Microbubbles for Cancer Therapy.International journal of molecular sciences · 2022Review
- Bevacizumab combined with re-irradiation in recurrent glioblastoma.Frontiers in oncology · 2022Article
- Emerging contrast-enhanced ultrasound applications in children.Pediatric radiology · 2021Review
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Pharmacokinetic Modeling of Targeted Ultrasound Contrast Agents for Quantitative Assessment of Anti-Angiogenic Therapy: a Longitudinal Case-Control Study in Colon Cancer.Molecular imaging and biology · 2019Article
- Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography.Translational oncology · 2018Article
- Multimodal photoacoustic imaging as a tool for sentinel lymph node identification and biopsy guidance.Biomedical engineering letters · 2018Review
- Thrombin-Activatable Microbubbles as Potential Ultrasound Contrast Agents for the Detection of Acute Thrombosis.ACS applied materials & interfaces · 2017Article
- Microbubbles used for contrast enhanced ultrasound and theragnosis: a review of principles to applications.Biomedical engineering letters · 2017Review
- Article
- Progress in the clinical detection of heterogeneity in breast cancer.Cancer medicine · 2016Review
- Three-dimensional Contrast-enhanced Ultrasound in Response Assessment for Breast Cancer: A Comparison with Dynamic Contrast-enhanced Magnetic Resonance Imaging and Pathology.Scientific reports · 2016Article
- RGD-Targeted Ultrasound Contrast Agent for Longitudinal Assessment of Hep-2 Tumor Angiogenesis In Vivo.PloS one · 2016Article
- Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney Injury.Molecular imaging and biology · 2015Article
- [Molecular ultrasound imaging: Clinical applications].Der Radiologe · 2015Review
- Ultrasound molecular imaging: Moving toward clinical translation.European journal of radiology · 2015Review
- Ultrasound molecular imaging of tumor angiogenesis with a neuropilin-1-targeted microbubble.Biomaterials · 2015Article
- Three-dimensional ultrasound molecular imaging of angiogenesis in colon cancer using a clinical matrix array ultrasound transducer.Investigative radiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesContrast-enhanced ultrasound (US) and targeted microbubbles have been shown to be advantageous for angiogenesis evaluation and disease staging in cancer. This study explored molecular US imaging of a multitargeted microbubble for assessing the early tumor response to antiangiogenic therapy.
methodsTarget receptor expression of 2LMP breast cancer cells was quantified by flow cytometric analysis and characterization established with antibodies against mouse α(V)β3- integrin, P-selectin, and vascular endothelial growth factor receptor 2. Tumor-bearing mice (n = 15 per group) underwent contrast-enhanced US imaging of multitargeted microbubbles. Microbubble accumulation was calculated by destruction-replenishment techniques and time-intensity curve analysis. On day 0, mice underwent baseline imaging. Next, therapy group mice were injected with a 0.2-mg dose of bevacizumab, and controls received matched saline injections. Imaging was repeated on days 1 and 3. After imaging was completed on day 3, the mice were euthanized and tumors excised. Histologic analysis of microvessel density and intratumoral necrosis was completed on tumor sections.
resultsOn day 3 after bevacizumab dosing, a 71.8% change in tumor vasculature was shown between the therapy and control groups (P = .01). The therapy group had a 15.4% decrease in tumor vascularity, whereas the control group had a 56.4% increase.
conclusionsMolecular US imaging of angiogenic markers can detect the early tumor response to drug therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.