ArticleNature communications2012
Computational design of self-assembling register-specific collagen heterotrimers.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Programmable Steric Control of Collagen Peptide-to-Fiber Assembly.Journal of the American Chemical Society · 2026Article
- Data-Driven Engineering of Thermostable Collagen-Mimetic Peptoid Triple Helices.Macromolecular rapid communications · 2026Article
- De Novo Design of Specific Heterotrimeric Collagen-Like Peptides via Genetic Algorithm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- β-Turn Mimicking Crosslinking Provides Hyperstability and Fast Folding Kinetics for Short Collagen Triple Helices.Chembiochem : a European journal of chemical biology · 2025Article
- Evaluation of Orientation-Dependent Cation-π Pairwise Effects within Collagen Triple Helices.The journal of physical chemistry. B · 2025Article
- Exploration of the hierarchical assembly space of collagen-like peptides beyond the triple helix.Nature communications · 2024Article
- Beyond the Triple Helix: Exploration of the Hierarchical Assembly Space of Collagen-like Peptides.bioRxiv : the preprint server for biology · 2024Article
- A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.The Journal of biological chemistry · 2023Article
- Article
- Predicting the stability of homotrimeric and heterotrimeric collagen helices.Nature chemistry · 2021Article
- Combining simulations and experiments for the molecular engineering of multifunctional collagen mimetic peptide-based materials.Soft matter · 2021Article
- Collagen Mimetic Peptides.Bioengineering (Basel, Switzerland) · 2021Review
- How electrostatic networks modulate specificity and stability of collagen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Structural basis of homo- and heterotrimerization of collagen I.Nature communications · 2017Article
- Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Journal of the American Chemical Society · 2016Article
- Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Journal of the American Chemical Society · 2016Article
- Rational design of fiber forming supramolecular structures.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Computationally Designed Bispecific Antibodies using Negative State Repertoires.Structure (London, England : 1993) · 2016Article
- Self-assembling peptides for stem cell and tissue engineering.Biomaterials science · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of pairwise amino-acid interactions to the stability of collagen triple helices has remained elusive. Progress in this area is critical for the prediction of triple helical stability from sequences and the preparation of mimetic materials based on this fold. Here we report a sequence-based scoring function for triple helices that takes into account the stability conferred to collagen by axial lysine-aspartate salt bridges. This function is used to predict the stability of a specific register formed from three distinct peptide sequences and that of all alternative compositions and registers. In the context of a genetic algorithm we use it to select sequences likely to self-assemble with high stability and to the exclusion of the other 26 possible combinations. We validate our methodology by synthesis and structural characterization of the designed peptides, which self-assemble into a highly stable ABC triple helix with control over both composition and register.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.