ArticleNature communications2012
Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 108 citations in OpenAlex.
- Filial Imprinting: Behaviour and Neurobiology.Behavioral sciences (Basel, Switzerland) · 2026Review
- Article
- Mother-Offspring Bonding after Calving in Water Buffalo and Other Ruminants: Sensory Pathways and Neuroendocrine Aspects.Animals : an open access journal from MDPI · 2024Review
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Thyroid hormone as a temporal switch in mouse development.European thyroid journal · 2023Review
- The Role of Oxytocin in Domestic Animal's Maternal Care: Parturition, Bonding, and Lactation.Animals : an open access journal from MDPI · 2023Review
- Mother-Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals.Animals : an open access journal from MDPI · 2023Review
- Parental behavior and newborn attachment in birds: life history traits and endocrine responses.Frontiers in psychology · 2023Review
- Temporal hampering of thyroid hormone synthesis just before hatching impeded the filial imprinting in domestic chicks.Frontiers in physiology · 2023Article
- Mating experiences with the same partner enhanced mating activities of naïve male medaka fish.Scientific reports · 2022Article
- Dairy Buffalo Behavior: Calving, Imprinting and Allosuckling.Animals : an open access journal from MDPI · 2022Review
- Effect of prenatal glucocorticoids and thyroid hormones on developmental plasticity of mitochondrial aerobic metabolism, growth and survival: an experimental test in wild great tits.The Journal of experimental biology · 2022Article
- Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc.Frontiers in physiology · 2022Article
- Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick.Cerebral cortex communications · 2022Article
- Mother-young bond in non-human mammals: Neonatal communication pathways and neurobiological basis.Frontiers in psychology · 2022Review
- Unraveling the Role of Thyroid Hormones in Seasonal Neuroplasticity in European Starlings (Frontiers in molecular neuroscience · 2022Article
- Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: AnFrontiers in physiology · 2022Article
- Allonursing in Wild and Farm Animals: Biological and Physiological Foundations and Explanatory Hypotheses.Animals : an open access journal from MDPI · 2021Review
- REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.Reproduction (Cambridge, England) · 2021Review
- Neurophysiological Mechanisms of Mother-Young Bonding in Buffalo and Other Farm Animals.Animals : an open access journal from MDPI · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filial imprinting in precocial birds is the process of forming a social attachment during a sensitive or critical period, restricted to the first few days after hatching. Imprinting is considered to be part of early learning to aid the survival of juveniles by securing maternal care. Here we show that the thyroid hormone 3,5,3'-triiodothyronine (T(3)) determines the start of the sensitive period. Imprinting training in chicks causes rapid inflow of T(3), converted from circulating plasma thyroxine by Dio2, type 2 iodothyronine deiodinase, in brain vascular endothelial cells. The T(3) thus initiates and extends the sensitive period to last more than 1 week via non-genomic mechanisms and primes subsequent learning. Even in non-imprinted chicks whose sensitive period has ended, exogenous T(3) enables imprinting. Our findings indicate that T(3) determines the start of the sensitive period for imprinting and has a critical role in later learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.