ArticleNature communications2012
Genetic architecture supports mosaic brain evolution and independent brain-body size regulation.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the interactions of antihistamine with retinoic acid receptor beta (RARB) by molecular dynamics simulations and genome-wide meta-analysis.Journal of molecular graphics & modelling · 2023Pooled it
- Exploring Larval Axolotl Brain Development: Insights Into Developmental and Functional Constraints.Evolution & development · 2026Article
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- Beyond the mosaic model of brain evolution: Rearing environment defines local and global plasticity.Annals of the New York Academy of Sciences · 2024Article
- Brain structural parameters correlate with University Selection Test outcomes in Chilean high school graduates.Scientific reports · 2022Article
- Divergence in brain size and brain region volumes across wild guppy populations.Proceedings. Biological sciences · 2022Article
- Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder.Biological psychiatry · 2022Review
- A dual larynx motor networks hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Rapid mosaic brain evolution under artificial selection for relative telencephalon size in the guppy (Science advances · 2021Article
- Novel neuroanatomical integration and scaling define avian brain shape evolution and development.eLife · 2021Article
- An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.BMC biology · 2021Article
- Article
- Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains.NeuroImage · 2020Article
- A brain and a head for a different habitat: Size variation in four morphs of Arctic charr (Ecology and evolution · 2020Article
- Comparative growth in the olfactory system of the developing chick with considerations for evolutionary studies.Journal of anatomy · 2020Article
- The genetic regulation of size variation in the transcriptome of the cerebrum in the chicken and its role in domestication and brain size evolution.BMC genomics · 2020Article
- Fungus-Growing Ants: Models for the Integrative Analysis of Cognition and Brain Evolution.Frontiers in behavioral neuroscience · 2020Article
- Behavioral evolution contributes to hindbrain diversification among Lake Malawi cichlid fish.Scientific reports · 2019Article
- Brain structure differences between solitary and social wasp species are independent of body size allometry.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.