ArticleMolecular systems biology2012
Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
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- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- A mathematical framework for understanding the spontaneous emergence of complexity applicable to growing multicellular systems.PLoS computational biology · 2024Article
- Reconstructing growth and dynamic trajectories from single-cell transcriptomics data.Nature machine intelligence · 2024Article
- The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation.Nature reviews. Genetics · 2023Review
- A bistable autoregulatory module in the developing embryo commits cells to binary expression fates.Current biology : CB · 2023Article
- Segmentation and patterning of the vertebrate hindbrain.Development (Cambridge, England) · 2021Review
- Multiple morphogens and rapid elongation promote segmental patterning during development.PLoS computational biology · 2021Article
- Implications of diffusion and time-varying morphogen gradients for the dynamic positioning and precision of bistable gene expression boundaries.PLoS computational biology · 2021Article
- A virtual sequencer reveals the dephasing patterns in error-correction code DNA sequencing.National science review · 2021Article
- Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation.Frontiers in cell and developmental biology · 2021Review
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.Journal of developmental biology · 2020Review
- STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS.Discrete and continuous dynamical systems. Series B · 2019Article
- Theoretical Models of Neural Development.iScience · 2018Review
- Landscape reveals critical network structures for sharpening gene expression boundaries.BMC systems biology · 2018Article
- Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain.Developmental cell · 2018Article
- Exploring intermediate cell states through the lens of single cells.Current opinion in systems biology · 2018Article
- Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis.Science (New York, N.Y.) · 2018Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Morphogens provide positional information for spatial patterns of gene expression during development. However, stochastic effects such as local fluctuations in morphogen concentration and noise in signal transduction make it difficult for cells to respond to their positions accurately enough to generate sharp boundaries between gene expression domains. During development of rhombomeres in the zebrafish hindbrain, the morphogen retinoic acid (RA) induces expression of hoxb1a in rhombomere 4 (r4) and krox20 in r3 and r5. Fluorescent in situ hybridization reveals rough edges around these gene expression domains, in which cells co-express hoxb1a and krox20 on either side of the boundary, and these sharpen within a few hours. Computational analysis of spatial stochastic models shows, surprisingly, that noise in hoxb1a/krox20 expression actually promotes sharpening of boundaries between adjacent segments. In particular, fluctuations in RA initially induce a rough boundary that requires noise in hoxb1a/krox20 expression to sharpen. This finding suggests a novel noise attenuation mechanism that relies on intracellular noise to induce switching and coordinate cellular decisions during developmental patterning.
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