ArticleHeredity2013
Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 79 citations in OpenAlex.
- Paternal leakage of mitochondrial DNA is genetically controlled in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Evidence for Paternal Mitochondrial DNA Leakage in Diploid Hybrid Fish Lineages.Animals : an open access journal from MDPI · 2026Article
- Pervasive non-random mitochondrial DNA heteroplasmy in the hybrid water frog Pelophylax esculentus.BMC ecology and evolution · 2025Article
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
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- Pervasive heteroplasmy in an invasive ambrosia beetle (Scolytinae) in southern California.Heredity · 2024Article
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- Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila.Genetics · 2024Article
- Reciprocal restriction fragment length polymorphism (RFLP) analysis reveals mitochondrial heteroplasmy inmicroPublication biology · 2024Article
- Review
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- The gender-specific impact of starvation on mitotypes diversity in adults ofOpen biology · 2022Article
- Independent evolution of highly variable, fragmented mitogenomes of parasitic lice.Communications biology · 2022Article
- Inheritance through the cytoplasm.Heredity · 2022Review
- Migration restores hybrid incompatibility driven by mitochondrial-nuclear sexual conflict.Proceedings. Biological sciences · 2022Article
- Selection for biparental inheritance of mitochondria under hybridization and mitonuclear fitness interactions.Proceedings. Biological sciences · 2021Article
- Mitochondrial function in development and disease.Disease models & mechanisms · 2021Review
- Genetic variation and heteroplasmy of Varroa destructor inferred from ND4 mtDNA sequences.Parasitology research · 2020Article
- Ancient hybridization and mtDNA introgression behind current paternal leakage and heteroplasmy in hybrid zones.Scientific reports · 2019Article
- Mitochondrial heteroplasmy in an avian hybrid form (Mitochondrial DNA. Part B, Resources · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal inheritance is one of the hallmarks of animal mitochondrial DNA (mtDNA) and central to its success as a molecular marker. This mode of inheritance and subsequent lack of heterologous recombination allows us to retrace evolutionary relationships unambiguously down the matriline and without the confounding effects of recombinant genetic information. Accumulating evidence of biparental inheritance of mtDNA (paternal leakage), however, challenges our current understanding of how this molecule is inherited. Here, using Drosophila simulans collected from an East African metapopulation exhibiting recurring mitochondrial heteroplasmy, we conducted single fly matings and screened F1 offspring for the presence of paternal mtDNA using allele-specific PCR assays (AS-PCR). In all, 27 out of 4092 offspring were identified as harboring paternal mtDNA, suggesting a frequency of 0.66% paternal leakage in this species. Our findings strongly suggest that recurring mtDNA heteroplasmy as observed in natural populations of Drosophila simulans is most likely caused by repeated paternal leakage. Our findings further suggest that this phenomenon to potentially be an integral part of mtDNA inheritance in these populations and consequently of significance for mtDNA as a molecular marker.
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