ArticleCerebral cortex (New York, N.Y. : 1991)2014
Quantification of early stages of cortical reorganization of the topographic map of V1 following retinal lesions in monkeys.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 33 citations in OpenAlex.
- Rapid topographic reorganization in adult human primary visual cortex (V1) during noninvasive and reversible deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cerebral Modifications and Visual Pathway Reorganization in Maculopathy: A Systematic Review.Frontiers in neuroscience · 2020Review
- Time course of cytochrome oxidase blob plasticity in the primary visual cortex of adult monkeys after retinal laser lesions.The Journal of comparative neurology · 2019Article
- Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma.Experimental brain research · 2017Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Precise visuotopic organization of the blind spot representation in primate V1.Journal of neurophysiology · 2015Article
- Adult cortical plasticity studied with chronically implanted electrode arrays.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cortical connective field estimates from resting state fMRI activity.Frontiers in neuroscience · 2014Article
- An updated midline rule: visual callosal connections anticipate shape and motion in ongoing activity across the hemispheres.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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5 authors at 2 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
We quantified the capacity for reorganization of the topographic representation of area V1 in adult monkeys. Bias-free automated mapping methods were used to delineate receptive fields (RFs) of an array of neuronal clusters prior to, and up to 6 h following retinal lesions. Monocular lesions caused a significant reorganization of the topographic map in this area, both inside and outside the cortical lesion projection zone (LPZ). Small flashed stimuli revealed responses up to 0.85 mm inside the boundaries of the LPZ, with RFs representing regions of undamaged retina immediately surrounding the lesion. In contrast, long moving bars that spanned the scotoma resulting from the lesion revealed responsive units up to 1.87 mm inside the LPZ, with RFs representing interpolated responses in this region. This reorganization is present immediately after monocular retinal lesioning. Both stimuli showed a similar and significant (5-fold) increase of the RF scatter in the LPZ, 0.56 mm (median), compared with the undamaged retina, 0.12 mm. Our results reveal an array of preexisting subthreshold functional connections of up to 2 mm in V1, which can be rapidly mobilized independently from the differential qualitative reorganization elicited by each stimulus.
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