Evidence map›Paper›PMID 23010594›Full record

ArticleFEBS letters2012

Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein.

Kirill Tsirulnikov, Natalia Abuladze, Ritu Vahi, Huma Hasnain, Martin Phillips, Christopher M Ryan, Ivo Atanasov, Kym F Faull, Ira Kurtz, Alexander Pushkin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kirill TsirulnikovDivision of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA. ktsirulnikov@mednet.ucla.edu
Natalia Abuladze
Ritu Vahi
Huma Hasnain
Martin Phillips
Christopher M Ryan
Ivo Atanasov
Kym F Faull
Ira Kurtz
Alexander Pushkin
University of California, Los Angeles · US

Funding

Biology of Mercapturic Acid Mediated NephrotoxicityR01ES012935 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PUSHKIN, ALEXANDER · 2005 to 2009
$1.8M
NEPHROLOGY SCIENTIST TRAINING GRANTT32DK007789 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURTZ, IRA · 2000 to 2017
$1.5M
NIDDK NIH HHS T32 DK007789NIDDK NIH HHS T32-DK-07789NIEHS NIH HHS ES012935NIEHS NIH HHS R01 ES012935
6 · The paper itself

Abstract

Aminoacylase 3 (AA3) mediates deacetylation of N-acetyl aromatic amino acids and mercapturic acids. Deacetylation of mercapturic acids of exo- and endobiotics are likely involved in their toxicity. AA3 is predominantly expressed in kidney, and to a lesser extent in liver, brain, and blood. AA3 has been recently reported to interact with the hepatitis C virus core protein (HCVCP) in the yeast two-hybrid system. Here we demonstrate that AA3 directly binds to HCVCP (K(d) ~10 μM) that may by implicated in HCV pathogenesis. AA3 also revealed a weak endopeptidase activity towards the N-terminus of HCVCP.

Indexed as

AmidohydrolasesAmino Acid SequenceAnimalsEscherichia coliHepacivirusHumansKineticsMiceMicroscopy, ElectronMolecular Sequence DataProtein BindingProteolysisRecombinant Fusion ProteinsSequence Homology, Amino AcidSolutionsSurface Plasmon ResonanceAmidohydrolasesaminoacylase III, mousenucleocapsid protein, Hepatitis C virusRecombinant Fusion ProteinsSolutionsViral Core Proteins

Identifiers

PMID23010594
PMCPMC3483449
OpenAlexW2086885026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.