ArticleDevelopmental biology2012
Jak-STAT regulation of cyst stem cell development in the Drosophila testis.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Lin28 Represses Hub Cell microRNAs to MaintainDevelopment & reproduction · 2026Review
- Metabolic Regulation in the Maintenance ofInternational journal of molecular sciences · 2026Review
- The Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila.Development (Cambridge, England) · 2026Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.Current biology : CB · 2024Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.bioRxiv : the preprint server for biology · 2024Article
- Lin28 is Required for Single Niche Development in theDevelopment & reproduction · 2023Article
- A conserved function of Human DLC3 andeLife · 2022Article
- Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.Developmental cell · 2022Article
- Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.Cell reports · 2022Article
- Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche.Developmental biology · 2019Article
- JAK/STAT signaling in stem cells and regeneration: fromDevelopment (Cambridge, England) · 2019Review
- Chinmo prevents transformer alternative splicing to maintain male sex identity.PLoS genetics · 2018Article
- Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis.PLoS genetics · 2017Article
- Apontic regulates somatic stem cell numbers in Drosophila testes.BMC developmental biology · 2016Article
- Traffic jam functions in a branched pathway from Notch activation to niche cell fate.Development (Cambridge, England) · 2015Article
- Drosophila's contribution to stem cell research.F1000Research · 2015Review
- Sonication-facilitated immunofluorescence staining of late-stage embryonic and larval Drosophila tissues in situ.Journal of visualized experiments : JoVE · 2014Article
- Conversion of quiescent niche cells to somatic stem cells causes ectopic niche formation in the Drosophila testis.Cell reports · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Establishment and maintenance of functional stem cells is critical for organ development and tissue homeostasis. Little is known about the mechanisms underlying stem establishment during organogenesis. Drosophila testes are among the most thoroughly characterized systems for studying stem cell behavior, with germline stem cells (GSCs) and somatic cyst stem cells (CySCs) cohabiting a discrete stem cell niche at the testis apex. GSCs and CySCs are arrayed around hub cells that also comprise the niche and communication between hub cells, GSCs, and CySCs regulates the balance between stem cell maintenance and differentiation. Recent data has shown that functional, asymmetrically dividing GSCs are first established at ∼23 h after egg laying during Drosophila testis morphogenesis (Sheng et al., 2009). This process correlates with coalescence of the hub, but development of CySCs from somatic gonadal precursors (SGPs) was not examined. Here, we show that functional CySCs are present at the time of GSC establishment, and that Jak-STAT signaling is necessary and sufficient for CySC maintenance shortly thereafter. Furthermore, hyper-activation of Jak in CySCs promotes expansion of the GSC population, while ectopic Jak activation in the germline induces GSC gene expression in GSC daughter cells but does not prevent spermatogenic differentiation. Together, these observations indicate that, similar to adult testes, Jak-STAT signaling from the hub acts on both GSCs and CySC to regulate their development and differentiation, and that additional signaling from CySCs to the GSCs play a dominant role in controlling GSC maintenance during niche formation.
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