ReviewNeurotoxicology and teratology
Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.
Review in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- tVNS alters inflammatory response in adult VPA-induced mouse model of autism: evidence for sexual dimorphism.FEBS open bio · 2025Article
- Effects and mechanisms of phthalates' action on neurological processes and neural health: a literature review.Pharmacological reports : PR · 2021Review
- Environmental Chemicals and Autism: A Scoping Review of the Human and Animal Research.Environmental health perspectives · 2019Article
- Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio.Environmental research · 2019Article
- Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Children's low-level pesticide exposure and associations with autism and ADHD: a review.Pediatric research · 2019Review
- Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice.Neurotoxicology · 2018Article
- Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism.Current environmental health reports · 2017Review
- Allergic fetal priming leads to developmental, behavioral and neurobiological changes in mice.Translational psychiatry · 2015Article
- Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain.BioMed research international · 2014Review
- Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective.Chemical research in toxicology · 2013Article
- Gene-environment interactions in genome-wide association studies: current approaches and new directions.Journal of child psychology and psychiatry, and allied disciplines · 2013Review
- Is 'bench-to-bedside' realistic for autism? An integrative neuroscience approach.Neuropsychiatry · 2013Article
- Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice.Translational psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To better study the role of genetics in autism, mouse models have been developed which mimic the genetics of specific autism spectrum and related disorders. These models have facilitated research on the role genetic susceptibility factors in the pathogenesis of autism in the absence of environmental factors. Inbred mouse strains have been similarly studied to assess the role of environmental agents on neurodevelopment, typically without the complications of genetic heterogeneity of the human population. What has not been as actively pursued, however, is the methodical study of the interaction between these factors (e.g., gene and environmental interactions in neurodevelopment). This review suggests that a genetic predisposition paired with exposure to environmental toxicants plays an important role in the etiology of neurodevelopmental disorders including autism, and may contribute to the largely unexplained rise in the number of children diagnosed with autism worldwide. Specifically, descriptions of the major mouse models of autism and toxic mechanisms of prevalent environmental chemicals are provided followed by a discussion of current and future research strategies to evaluate the role of gene and environment interactions in neurodevelopmental disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.