ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2012
αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation.Journal of immunotoxicology · 2024Article
- Respiratory Diseases Associated With Organic Dust Exposure.The journal of allergy and clinical immunology. In practice · 2024Review
- Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures.Respiratory research · 2024Article
- Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy.Scientific reports · 2022Article
- Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation.Respiratory research · 2021Article
- Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10.Journal of immunotoxicology · 2020Article
- Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease.The World Allergy Organization journal · 2020Article
- Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Association Between Organic Dust Exposure and Adult-Asthma: A Systematic Review and Meta-Analysis of Case-Control Studies.Allergy, asthma & immunology research · 2019Article
- Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust.Respiratory research · 2019Article
- RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.Cancer cell · 2018Article
- Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers.Respiratory research · 2018Article
- The Effect of Inhalant Organic Dust on Bone Health.Current allergy and asthma reports · 2018Review
- A role for B cells in organic dust induced lung inflammation.Respiratory research · 2017Article
- Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice.Safety (Basel, Switzerland) · 2017Article
- Systemic IL-6 Effector Response in Mediating Systemic Bone Loss Following Inhalation of Organic Dust.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2017Article
- RSV-specific anti-viral immunity is disrupted by chronic ethanol consumption.Alcohol (Fayetteville, N.Y.) · 2016Article
- Occupational agriculture organic dust exposure and its relationship to asthma and airway inflammation in adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Review
- Interaction of TIM4 and TIM3 induces T helper 1 cell apoptosis.Immunologic research · 2016Article
- Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust.Translational research : the journal of laboratory and clinical medicine · 2015Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOrganic dust exposure in agricultural environments induces an inflammatory response that attenuates over time, yet repetitive dust exposures result in chronic lung diseases. Animal models resembling this chronic lung inflammatory response have been developed, yet the underlying cellular mechanisms are not well defined.
objectiveBecause mice repetitively exposed to organic dust extracts (DE) display increased CD3+ T cell lung infiltrates, we sought to determine the phenotype and importance of these cells.
methodsMice received swine confinement DE repetitively for 3 weeks by established intranasal inhalation protocol. Studies were conducted with peptidoglycan (PGN) because it is a major DE component in large animal farming environments and has shared similar biologic effects with DE. Enumeration of T cells and intracellular cytokine profiles were conducted by flow cytometry techniques. Whole lung homogenate cytokines were analyzed by multiplex immunoassay. T cell receptor (TCR) αβ knockouts were used to determine the functional importance of αβ-expressing T cells.
resultsDE increased lung-associated CD3+CD4+ T cells and interleukin (IL)-17 (but not IL-4, interferon [IFN]-γ, IL-10) producing CD4+ T cells. PGN treatment resulted in increased IL-17 and IFN-γ producing CD4+ T cells and IFN-γ producing CD8+ T cells. Both DE and PGN augmented expression of cytokines associated with Th1 and Th17 polarization in lung homogenates. DE-induced lung mononuclear aggregates and bronchiolar compartment inflammation were significantly reduced in TCR knockout animals; however, neutrophil influx and alveolar compartment inflammation were not affected.
conclusionStudies demonstrated that DE and PGN exposure promote a Th1/Th17 lung microenvironment and that αβ-expressing T cells are important in mediating DE-induced lung pathologic conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.