Trial reportAmerican journal of obstetrics and gynecology2012
17 alpha-hydroxyprogesterone caproate to prevent prematurity in nulliparas with cervical length less than 30 mm.
Trial report in American journal of obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02901626 (A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix), which is not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.American journal of obstetrics and gynecology · 2018Pooled it
- 17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2016Pooled it
- A systematic review and meta-analysis of progestogen use for maintenance tocolysis after preterm labor in women with intact membranes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2016Pooled it
- Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth.The Cochrane database of systematic reviews · 2013Pooled it
- Relationship between plasma concentration of 17-hydroxyprogesterone caproate and gestational age at preterm delivery.American journal of obstetrics & gynecology MFM · 2023Trial
- Prediction of Spontaneous Preterm Birth Among Nulliparous Women With a Short Cervix.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2016Trial
- Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth.American journal of obstetrics and gynecology · 2014Trial
- Review
- Challenges in Using Progestin to Prevent Singleton Preterm Births: Current Knowledge and Clinical Advice.International journal of women's health · 2024Review
- What now? A critical evaluation of over 20 years of clinical and research experience with 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention.American journal of obstetrics & gynecology MFM · 2023Review
- Different effects for different questions: An illustration using short cervix and the risk of preterm birth.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Article
- Progesterone, cerclage, pessary, or acetylsalicylic acid for prevention of preterm birth in singleton and multifetal pregnancies - A systematic review and meta-analyses.Frontiers in medicine · 2023Review
- 17-alpha hydroxyprogesterone caproate for the prevention of recurrent preterm birth among singleton pregnant women with a prior history of preterm birth: a systematic review and meta-analysis of six randomized controlled trials.Obstetrics & gynecology science · 2021Article
- Prevention of Preterm Birth with Progesterone.Journal of clinical medicine · 2021Review
- Cervical length distribution and other sonographic ancillary findings of singleton nulliparous patients at midgestation.American journal of obstetrics and gynecology · 2021Article
- Cost-Effectiveness of a Proteomic Test for Preterm Birth Prediction.ClinicoEconomics and outcomes research : CEOR · 2021Article
- Second-trimester transvaginal ultrasound measurement of cervical length for prediction of preterm birth: a blinded prospective multicentre diagnostic accuracy study.BJOG : an international journal of obstetrics and gynaecology · 2021Observational
- Current Approaches to Risk Assessment and Prevention of Preterm Birth-A Continuing Public Health Crisis.Ochsner journal · 2020Review
- Pharmacokinetics and tolerability of a novel progesterone intravaginal ring in sheep.Drug delivery and translational research · 2019Article
- Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2018Article
Corrections and comments
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Authors and funding
18 authors at 17 institutions in 1 country.
Funding
Abstract
objectiveWe sought to evaluate whether 17 alpha-hydroxyprogesterone caproate (17-OHP) reduces preterm birth (PTB) in nulliparous women with a midtrimester cervical length (CL) <30 mm. STUDY
designIn this multicenter randomized controlled trial, nulliparous women with a singleton gestation between 16 and 22 3/7 weeks with an endovaginal CL <30 mm (<10th percentile in this population) were randomized to weekly intramuscular 17-OHP (250 mg) or placebo through 36 weeks. The primary outcome was PTB <37 weeks.
resultsThe frequency of PTB did not differ between the 17-OHP (n = 327) and placebo (n = 330) groups (25.1% vs 24.2%; relative risk, 1.03; 95% confidence interval, 0.79-1.35). There also was no difference in the composite adverse neonatal outcome (7.0% vs 9.1%; relative risk, 0.77; 95% confidence interval, 0.46-1.30).
conclusionWeekly 17-OHP does not reduce the frequency of PTB in nulliparous women with a midtrimester CL <30 mm.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.