ArticleDevelopmental biology2012
Distinct spatiotemporal roles of hedgehog signalling during chick and mouse cranial base and axial skeleton development.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cranial base synostosis in mice caused by upregulation of Wnt following partial inhibition of Shh.BMC biology · 2025Article
- The Genetics of Chiari 1 Malformation.Journal of clinical medicine · 2024Review
- The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.Disease models & mechanisms · 2022Review
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Review
- ADAM10 modulates SOX9 expressionRSC advances · 2018Article
- Neural crest and the origin of species-specific pattern.Genesis (New York, N.Y. : 2000) · 2018Review
- The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation.International journal of molecular sciences · 2018Article
- Developmental dynamics of occipital and cervical somites.Journal of anatomy · 2016Article
- An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull.Developmental biology · 2016Article
- Genetically induced abnormal cranial development in human trisomy 18 with holoprosencephaly: comparisons with the normal tempo of osteogenic-neural development.Journal of anatomy · 2015Article
- Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain.BioMed research international · 2015Article
- Skull base embryology: a multidisciplinary review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Review
- Fine tuning of craniofacial morphology by distant-acting enhancers.Science (New York, N.Y.) · 2013Article
- The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects.Genesis (New York, N.Y. : 2000) · 2013Article
- Angiogenesis and intramembranous osteogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Review
- The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling.BMC biology · 2013Article
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Authors and funding
7 authors.
Funding
Abstract
The cranial base exerts a supportive role for the brain and includes the occipital, sphenoid and ethmoid bones that arise from cartilaginous precursors in the early embryo. As the occipital bone and the posterior part of the sphenoid are mesoderm derivatives that arise in close proximity to the notochord and floor plate, it has been assumed that their development, like the axial skeleton, is dependent on Sonic hedgehog (Shh) and modulation of bone morphogenetic protein (Bmp) signalling. Here we examined the development of the cranial base in chick and mouse embryos to compare the molecular signals that are required for chondrogenic induction in the trunk and head. We found that Shh signalling is required but the molecular network controlling cranial base development is distinct from that in the trunk. In the absence of Shh, the presumptive cranial base did not undergo chondrogenic commitment as determined by the loss of Sox9 expression and there was a decrease in cell survival. In contrast, induction of the otic capsule occurred normally demonstrating that induction of the cranial base is uncoupled from formation of the sensory capsules. Lastly, we found that the early cranial mesoderm is refractory to Shh signalling, likely accounting for why development of the cranial base occurs after the axial skeleton. Our data reveal that cranial and axial skeletal induction is controlled by conserved, yet spatiotemporally distinct mechanisms that co-ordinate development of the cranial base with that of the cranial musculature and the pharyngeal arches.
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