ArticleGene2012
Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.
Article in Gene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.Human genetics · 2014Pooled it
- Polygenic prediction of cellular immune responses to mumps vaccine.Genes and immunity · 2025Article
- Will Omics Biotechnologies Save Us from Future Pandemics? Lessons from COVID-19 for Vaccinomics and Adversomics.Biomedicines · 2022Review
- Human Variation in DNA Repair, Immune Function, and Cancer Risk.Frontiers in immunology · 2022Review
- Effect of Serial Passage on the Pathogenicity and Immunogenicity of Vaccinia Virus LC16m8 Strain.Biology · 2021Review
- Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in theHuman vaccines & immunotherapeutics · 2020Article
- Article
- Causality assessment of adverse events following immunization: the problem of multifactorial pathology.F1000Research · 2020Article
- Statistical Methods for Testing Genetic Pleiotropy.Genetics · 2016Article
- Defending against smallpox: a focus on vaccines.Expert review of vaccines · 2016Review
- Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.Age and ageing · 2015Article
- Adversomics: a new paradigm for vaccine safety and design.Expert review of vaccines · 2015Review
- Changing face of vaccination in immunocompromised hosts.Current infectious disease reports · 2014Article
- HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study.Human genetics · 2014Article
- Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.Immunogenetics · 2014Article
- Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts.Vaccine · 2014Article
- Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Immunologic research · 2014Article
- Cytokine production associated with smallpox vaccine responses.Immunotherapy · 2014Review
- Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship.The Journal of infectious diseases · 2013Article
- Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals.Human immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We explored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subjects following primary smallpox vaccination. We also analyzed the genotype-phenotype associations discovered in the Caucasian subjects among a cohort of African-Americans. In Caucasians we found 277 associations (p<0.05) between gene SNPs and inter-individual variations in IFN-α, IL-12p40, IL-1β, IL-2, and TNF-α secretion levels. A collection of SNPs in the IL1RN, IL2RB, IL4R, IL6, IL10RB, IL12A, and IL12RB2 genes had consistent associations among both Caucasians and African-Americans. A regulatory SNP (rs452204) in the IL1RN gene was significantly associated with higher levels of IL-2 secretion in an allele dose-dependent manner in both race groups (p=0.05 for Caucasians and p=0.002 for African-Americans). IL12RB2 polymorphism rs3790567 was associated with a dose-related decrease in IL-1β secretion (p=0.009 for Caucasians and p=0.01 for African-Americans). Our results demonstrate that variations in smallpox vaccine-induced cytokine responses are modulated by genetic polymorphisms in cytokine and cytokine receptor genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.