ArticleBMC genomics2012
Surviving in a toxic world: transcriptomics and gene expression profiling in response to environmental pollution in the critically endangered European eel.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 82 citations in OpenAlex.
- Fish diversity assessment through conventional morphological identification and recent advances in Saudi Arabia: A review.Veterinary world · 2024Review
- Abiotic and past climatic conditions drive protein abundance variation among natural populations of the caddisfly Crunoecia irrorata.Scientific reports · 2020Article
- Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent.Molecular ecology · 2019Article
- Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs).Scientific reports · 2019Article
- The expression profiles of miRNA-mRNA of early response in genetically improved farmed tilapia (Oreochromis niloticus) liver by acute heat stress.Scientific reports · 2017Article
- Rapid de novo assembly of the European eel genome from nanopore sequencing reads.Scientific reports · 2017Article
- Detecting the exposure to Cd and PCBs by means of a non-invasive transcriptomic approach in laboratory and wild contaminated European eels (Anguilla anguilla).Environmental science and pollution research international · 2016Article
- Transcriptome sequencing based annotation and homologous evidence based scaffolding of Anguilla japonica draft genome.BMC genomics · 2016Article
- Selection of best-performing reference gene products for investigating transcriptional regulation across silvering in the European eel (Anguilla anguilla).Scientific reports · 2015Article
- Genomics of Adaptation to Multiple Concurrent Stresses: Insights from Comparative Transcriptomics of a Cichlid Fish from One of Earth's Most Extreme Environments, the Hypersaline Soda Lake Magadi in Kenya, East Africa.Journal of molecular evolution · 2015Article
- Differences in brain gene transcription profiles advocate for an important role of cognitive function in upstream migration and water obstacles crossing in European eel.BMC genomics · 2015Article
- Transcriptomic responses of corpuscle of Stannius gland of Japanese eels (Anguilla japonica) to changes in water salinity.Scientific reports · 2015Article
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- Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels.Ecotoxicology (London, England) · 2015Article
- Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation.BMC genomics · 2014Article
- In absence of local adaptation, plasticity and spatially varying selection rule: a view from genomic reaction norms in a panmictic species (Anguilla rostrata).BMC genomics · 2014Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenomic and transcriptomic approaches have the potential for unveiling the genome-wide response to environmental perturbations. The abundance of the catadromous European eel (Anguilla anguilla) stock has been declining since the 1980s probably due to a combination of anthropogenic and climatic factors. In this paper, we explore the transcriptomic dynamics between individuals from high (river Tiber, Italy) and low pollution (lake Bolsena, Italy) environments, which were measured for 36 PCBs, several organochlorine pesticides and brominated flame retardants and nine metals.
resultsTo this end, we first (i) updated the European eel transcriptome using deep sequencing data with a total of 640,040 reads assembled into 44,896 contigs (Eeelbase release 2.0), and (ii) developed a transcriptomic platform for global gene expression profiling in the critically endangered European eel of about 15,000 annotated contigs, which was applied to detect differentially expressed genes between polluted sites. Several detoxification genes related to metabolism of pollutants were upregulated in the highly polluted site, including genes that take part in phase I of the xenobiotic metabolism (CYP3A), phase II (glutathione-S-transferase) and oxidative stress (glutathione peroxidase). In addition, key genes in the mitochondrial respiratory chain and oxidative phosphorylation were down-regulated at the Tiber site relative to the Bolsena site.
conclusionsTogether with the induced high expression of detoxification genes, the suggested lowered expression of genes supposedly involved in metabolism suggests that pollution may also be associated with decreased respiratory and energy production.
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