ArticleThyroid : official journal of the American Thyroid Association2013
Telomere length is shorter in affected members of families with familial nonmedullary thyroid cancer.
Article in Thyroid : official journal of the American Thyroid Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- Susceptibility Genes and Chromosomal Regions Associated With Non-Syndromic Familial Non-Medullary Thyroid Carcinoma: Some Pathogenetic and Diagnostic Keys.Frontiers in endocrinology · 2022Review
- Familial non-medullary thyroid cancer: a critical review.Journal of endocrinological investigation · 2021Review
- Review
- Co-Occurrence of Familial Non-Medullary Thyroid Cancer (FNMTC) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Associated Tumors-A Cohort Study.Frontiers in endocrinology · 2021Article
- Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer.Genes · 2020Review
- A Germline Mutation in theCancers · 2020Article
- Lack of Mutations in POT1 Gene in Selected Families with Familial Non-Medullary Thyroid Cancer.Hormones & cancer · 2020Article
- Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.Carcinogenesis · 2017Article
- Telomere content and risk of second malignant neoplasm in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Controversies in familial thyroid cancer 2014.Ulusal cerrahi dergisi · 2014Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe theory that short telomere length and genetic defects in maintaining telomere length are associated with familial nonmedullary thyroid cancer (FNMTC) is controversial. Thus, the aim of this study was to determine whether telomere length and genes involved in maintaining telomere length are altered in FNMTC.
methodsBlood samples were collected from 44 members (13 affected and 31 unaffected) of six families with FNMTC and from 60 controls. Quantitative polymerase chain reaction (Q-PCR) and reverse transcription PCR were performed to analyze relative telomere length (RTL), gene copy number, and mRNA expression of telomerase reverse transcriptase (hTERT), telomere repeat binding factor 1 (TRF1), telomere repeat binding factor 2 (TRF2), repressor activator protein 1 (RAP1), TRF1 interacting nuclear factor 2 (TIN2), tripeptidyl peptidase 1 (TPP1), and protection of telomere 1 (POT1).
resultsAffected members had shorter RTL, as compared with unaffected members (0.98 vs. 1.23, p<0.01). There was no significant difference in hTERT, TRF1, TRF2, RAP1, TIN2, TPP1, and POT1 gene copy number or mRNA expression between affected and unaffected members.
conclusionsRTL is shorter in affected members with FNMTC but is not associated with altered copy number or expression in hTERT, TRF1, TRF2, RAP1, TIN2, TPP1, and POT1. The small differences in RTL preclude the utility of RTL as a marker for FNMTC in at-risk individuals.
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