ArticleInternational journal of evolutionary biology2012
In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation.
Article in International journal of evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans.Nature ecology & evolution · 2022Article
- DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans.Nature communications · 2021Article
- BLAST from the Past: Impacts of Evolving Approaches on Studies of Evolution by Gene Duplication.Genome biology and evolution · 2021Article
- Methylamine-specific methyltransferase paralogs in Methanosarcina are functionally distinct despite frequent gene conversion.The ISME journal · 2019Article
- Old Trade, New Tricks: Insights into the Spontaneous Mutation Process from the Partnering of Classical Mutation Accumulation Experiments with High-Throughput Genomic Approaches.Genome biology and evolution · 2019Review
- Mutational and transcriptional landscape of spontaneous gene duplications and deletions inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional redundancy and nonredundancy between two Troponin C isoforms inMolecular biology of the cell · 2017Article
- Rapid Functional and Sequence Differentiation of a Tandemly Repeated Species-Specific Multigene Family in Drosophila.Molecular biology and evolution · 2017Article
- The comparative landscape of duplications in Heliconius melpomene and Heliconius cydno.Heredity · 2017Article
- LINE-1-like retrotransposons contribute to RNA-based gene duplication in dicots.Scientific reports · 2016Article
- The Planorbid Snail Biomphalaria glabrata Expresses a Hemocyanin-Like Sequence in the Albumen Gland.PloS one · 2016Article
- Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans.BMC genomics · 2015Article
- Early evolutionary history and genomic features of gene duplicates in the human genome.BMC genomics · 2015Article
- Neofunctionalization of the Sec1 α1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.PLoS pathogens · 2015Article
- Transcriptional control of an essential ribozyme in Drosophila reveals an ancient evolutionary divide in animals.PLoS genetics · 2015Article
- Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in a Drosophila melanogaster population.Molecular biology and evolution · 2015Article
- Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals.Genome biology and evolution · 2014Article
- Enhanced evolution by stochastically variable modification of epigenetic marks in the early embryo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Copy-number changes in evolution: rates, fitness effects and adaptive significance.Frontiers in genetics · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene duplication process has exhibited far greater promiscuity in the creation of paralogs with novel exon-intron structures than anticipated even by Ohno. In this paper I explore the history of the field, from the neo-Darwinian synthesis through Ohno's formulation of the canonical model for the evolution of gene duplicates and culminating in the present genomic era. I delineate the major tenets of Ohno's model and discuss its failure to encapsulate the full complexity of the duplication process as revealed in the era of genomics. I discuss the diverse classes of paralogs originating from both DNA- and RNA-mediated duplication events and their evolutionary potential for assuming radically altered functions, as well as the degree to which they can function unconstrained from the pressure of gene conversion. Lastly, I explore theoretical population-genetic considerations of how the effective population size (N(e)) of a species may influence the probability of emergence of genes with radically altered functions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.