ArticleInternational journal of endocrinology2012
Osteoarticular changes in acromegaly.
Article in International journal of endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Calcaneal quantitative ultrasound parameters strongly correlate with DXA measurements in patients with acromegaly.Pituitary · 2026Observational
- The Journey of Acromegaly Towards Treatment: A Single-Center Study.Journal of personalized medicine · 2026Article
- Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.Frontiers in veterinary science · 2026Article
- Cartilage thickness distribution and its dependence on demographic, radiographic, and MRI structural pathology in knee osteoarthritis-data from the IMI-APPROACH cohort.Skeletal radiology · 2025Article
- Possibility of calcification of type I collagen matrix in growth hormone-secreting pituitary neuroendocrine tumor.Surgical neurology international · 2025Article
- Clinical and functional outcome of total hip arthroplasty in patients with acromegaly: mean twelve year follow-up.International orthopaedics · 2022Article
- The intriguing giant deer from the Bate cave (Crete): could paleohistological evidence question its taxonomy and nomenclature?Integrative zoology · 2022Article
- [Articular manifestations in acromegaly: diagnostic and therapeutic implications of the coexistence of acromegalic arthropathy and rheumatoid arthritis].Anales del sistema sanitario de Navarra · 2021Article
- Imaging of sacroiliac joints in patients with acromegaly.Scientific reports · 2019Observational
- The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly.Zeitschrift fur Rheumatologie · 2017Article
- Patient-focussed outcomes in acromegaly.Pituitary · 2014Article
- On the functional capacity and quality of life of patients with acromegaly: are they candidates for rehabilitation programs?Journal of physical therapy science · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-I (IGF-1) due to pituitary tumor. Other causes, such as increased growth-hormone releasing hormone (GHRH) production, ectopic GHRH production, and ectopic GH secretion, are rare. Growth hormone and IGF-1 play a role in the regulation of bone metabolism, but accurate effect of growth hormone excess on bone is not fully explained. The issue of osteoarticular manifestations is still very actual, due to development of complications in the majority of patients with acromegaly. Traditionally, acromegaly is considered as a cause of secondary osteoporosis. Nowadays, it is discussed if BMD as predictor of osteoporotic fractures in acromegalic patient is decreased or even normal. Thus, bone quality remains to be more important in assessment of fracture risk. GH excess leads to increased bone turnover, defined by changes of bone markers. The articular manifestations are frequent clinical complications and may be present as the earliest symptom in a significant proportion of acromegalic patients. Articular manifestations are the main causes of morbidity and immobility of these patients, and they are persistent even after successful treatment. Quick recognition of osteoarticular changes and aiming the therapy lead to decrease in complication number.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.