ArticleEndocrinology2012
Rhesus monkey cumulus cells revert to a mural granulosa cell state after an ovulatory stimulus.
Article in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Dynamic changes in gene expression of growing nonhuman primate antral follicles.Physiological genomics · 2024Article
- Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China.Journal of ovarian research · 2023Article
- Heat-induced increases in body temperature in lactating dairy cows: impact on the cumulus and granulosa cell transcriptome of the periovulatory follicle.Journal of animal science · 2022Article
- Disruptions in follicle cell functions in the ovaries of rhesus monkeys during summer.Physiological genomics · 2015Article
- Transgenerational effects of binge drinking in a primate model: implications for human health.Fertility and sterility · 2015Article
- Dietary sugar in healthy female primates perturbs oocyte maturation and in vitro preimplantation embryo development.Endocrinology · 2014Article
- Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos.Physiological genomics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Follicular somatic cells (mural granulosa cells and cumulus cells) and the oocyte communicate through paracrine interactions and through direct gap junctions between oocyte and cumulus cells. Considering that mural and cumulus cells arise through a common developmental pathway and that their differentiation is essential to reproductive success, understanding how these cells differ is a key aspect to understanding their critical functions. Changes in global gene expression before and after an ovulatory stimulus were compared between cumulus and mural granulosa cells to test the hypothesis that mural and cumulus cells are highly differentiated at the time of an ovulatory stimulus and further differentiate during the periovulatory interval. The transcriptomes of the two cell types were markedly different (>1500 genes) before an ovulatory hCG bolus but converged after ovulation to become completely overlapping. The predominant transition was for the cumulus cells to become more like mural cells after hCG. This indicates that the differentiated phenotype of the cumulus cell is not stable and irreversibly established but may rather be an ongoing physiological response to the oocyte.
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Registered trials
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