ArticlePlant physiology2012
An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant defenses.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- The Circadian Clock Regulates Receptor-Mediated Immune Responses to a Herbivore-Associated Molecular Pattern.Plant, cell & environment · 2026Article
- Natural variation in expression of a plant immune receptor mediates elicitor sensitivity.PloS one · 2026Article
- Natural variation in expression of a plant immune receptor mediates elicitor sensitivity.bioRxiv : the preprint server for biology · 2025Article
- Planthopper protein Nlsp5 is essential for salivary sheath formation and acts as a HAMP inducing plant resistance to insects.Plant biotechnology journal · 2025Article
- Wound-induced transcriptional dynamics in rice.Crop health · 2025Article
- An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- BSR1, a Rice Receptor-like Cytoplasmic Kinase, Positively Regulates Defense Responses to Herbivory.International journal of molecular sciences · 2023Article
- Dynamic environmental interactions shaped by vegetative plant volatiles.Natural product reports · 2023Review
- Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition.eLife · 2022Article
- Molecular and Biochemical Mechanisms of Elicitors in Pest Resistance.Life (Basel, Switzerland) · 2022Review
- Molecular tug-of-war: Plant immune recognition of herbivory.The Plant cell · 2022Review
- A plant surface receptor for sensing insect herbivory.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A receptor-like protein mediates plant immune responses to herbivore-associated molecular patterns.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Spider Mites Cause More Damage to Tomato in the Dark When Induced Defenses Are Lower.Journal of chemical ecology · 2020Article
- The Role of Peptide Signals Hidden in the Structure of Functional Proteins in Plant Immune Responses.International journal of molecular sciences · 2019Review
- Plant Perception and Short-Term Responses to Phytophagous Insects and Mites.International journal of molecular sciences · 2018Review
- Transcriptome profiling revealed novel transcriptional regulators in maize responses to Ostrinia furnacalis and jasmonic acid.PloS one · 2017Article
- MATI, a Novel Protein Involved in the Regulation of Herbivore-Associated Signaling Pathways.Frontiers in plant science · 2017Article
- The Salivary Protein Repertoire of the Polyphagous Spider Mite Tetranychus urticae: A Quest for Effectors.Molecular & cellular proteomics : MCP · 2016Article
- The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions.The Plant cell · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants respond to insect herbivory through the production of biochemicals that function as either direct defenses or indirect defenses via the attraction of natural enemies. While attack by closely related insect pests can result in distinctive levels of induced plant defenses, precise biochemical mechanisms responsible for differing responses remain largely unknown. Cowpea (Vigna unguiculata) responds to Fall armyworm (Spodoptera frugiperda) herbivory through the detection of fragments of chloroplastic ATP synthase γ-subunit proteins, termed inceptin-related peptides, present in larval oral secretions (OS). In contrast to generalists like Fall armyworm, OS of the legume-specializing velvetbean caterpillar (VBC; Anticarsia gemmatalis) do not elicit ethylene production and demonstrate significantly lower induced volatile emission in direct herbivory comparisons. Unlike all other Lepidoptera OS examined, which preferentially contain inceptin (Vu-In; +ICDINGVCVDA-), VBC OS contain predominantly a C-terminal truncated peptide, Vu-In(-A) (+ICDINGVCVD-). Vu-In(-A) is both inactive and functions as a potent naturally occurring antagonist of Vu-In-induced responses. To block antagonist production, amino acid substitutions at the C terminus were screened for differences in VBC gut proteolysis. A valine-substituted peptide (Vu-In(ΔV); +ICDINGVCVDV-) retaining full elicitor activity was found to accumulate in VBC OS. Compared with the native polypeptide, VBC that previously ingested 500 pmol of the valine-modified chloroplastic ATP synthase γ-subunit precursor elicited significantly stronger plant responses in herbivory assays. We demonstrate that a specialist herbivore minimizes the activation of defenses by converting an elicitor into an antagonist effector and identify an amino acid substitution that recovers these induced plant defenses to a level observed with generalist herbivores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.