ArticleProteomics2012
Proteome variation among Filifactor alocis strains.
Article in Proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- The impact ofFrontiers in dental medicine · 2024Review
- Whole Genome Sequencing and Phenotypic Analysis of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Characterization of FA1654: A putative DPS protein in Filifactor alocis.Molecular oral microbiology · 2023Article
- Article
- Extracellular Vesicle Subproteome Differences amongMicroorganisms · 2022Article
- Proteomic Characterization of the Oral PathogenPathogens (Basel, Switzerland) · 2022Article
- Role of the Filifactor alocis Hypothetical Protein FA519 in Oxidative Stress Resistance.Microbiology spectrum · 2021Article
- Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context.The ISME journal · 2021Article
- Phylogenetic Analysis ofToxins · 2020Article
- Role of Superoxide Reductase FA796 in Oxidative Stress Resistance in Filifactor alocis.Scientific reports · 2020Article
- Regulation of matrix metalloproteinase-1 by Filifactor alocis in human gingival and monocytic cells.Clinical oral investigations · 2020Article
- Oral Dysbiotic Communities and Their Implications in Systemic Diseases.Dentistry journal · 2018Review
- Filifactor alocis collagenase can modulate apoptosis of normal oral keratinocytes.Molecular oral microbiology · 2017Article
- Filifactor alocis Promotes Neutrophil Degranulation and Chemotactic Activity.Infection and immunity · 2016Article
- FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.Immunological reviews · 2016Review
- Filifactor alocis--a new emerging periodontal pathogen.Microbes and infection · 2015Article
- Review
- The Biofilm Community-Rebels with a Cause.Current oral health reports · 2015Article
- Proteome analysis of coinfection of epithelial cells with Filifactor alocis and Porphyromonas gingivalis shows modulation of pathogen and host regulatory pathways.Infection and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Filifactor alocis, a Gram-positive anaerobic rod, is now considered one of the marker organisms associated with periodontal disease. Although there was heterogeneity in its virulence potential, this bacterium was shown to have virulence properties that may enhance its ability to survive and persist in the periodontal pocket. To gain further insight into a possible mechanism(s) of pathogenesis, the proteome of F. alocis strains was evaluated. Proteins including several proteases, neutrophil-activating protein A and calcium-binding acid repeat protein, were identified in F. alocis. During the invasion of HeLa cells, there was increased expression of several of the genes encoding these proteins in the potentially more virulent F. alocis D-62D compared to F. alocis ATCC 35896, the type strain. A comparative protein in silico analysis of the proteome revealed more cell wall anchoring proteins in the F. alocis D-62D compared to F. alocis ATCC 35896. Their expression was enhanced by coinfection with Porphyromonas gingivalis. Taken together, the variation in the pathogenic potential of the F. alocis strains may be related to the differential expression of several putative virulence factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.