Evidence map›Paper›PMID 23007965›Full record

ArticleJournal of the American Society for Mass Spectrometry2012

De novo correction of mass measurement error in low resolution tandem MS spectra for shotgun proteomics.

Jarrett D Egertson, Jimmy K Eng, Michael S Bereman, Edward J Hsieh, Gennifer E Merrihew, Michael J MacCoss

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Learning Peptide-Spectrum Alignment Models for Tandem Mass Spectrometry.Uncertainty in artificial intelligence : proceedings of the ... conference. Conference on Uncertainty in Artificial Intelligence · 2014
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jarrett D EgertsonDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Jimmy K Eng
Michael S Bereman
Edward J Hsieh
Gennifer E Merrihew
Michael J MacCoss

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
Analysis of Protein Dynamics in C. elegans by mLC/MS/MSR01DK069386 · NIDDK · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2006 to 2013
$2.3M
Time-Course Proteomics to Uncover the Mechanism and Nature of Aging in C. elegansF31AG037265 · NIA · UNIVERSITY OF WASHINGTON · PI EGERTSON, JARRETT DAVID · 2010 to 2013
$111k
NIA NIH HHS F31 AG037265NIDDK NIH HHS R01 DK069386NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

We report an algorithm designed for the calibration of low resolution peptide mass spectra. Our algorithm is implemented in a program called FineTune, which corrects systematic mass measurement error in 1 min, with no input required besides the mass spectra themselves. The mass measurement accuracy for a set of spectra collected on an LTQ-Velos improved 20-fold from -0.1776 ± 0.0010 m/z to 0.0078 ± 0.0006 m/z after calibration (avg ± 95 % confidence interval). The precision in mass measurement was improved due to the correction of non-linear variation in mass measurement accuracy across the m/z range.

Indexed as

AlgorithmsCalibrationModels, MolecularPeptide FragmentsPeptide MappingProteomicsSaccharomyces cerevisiae ProteinsSensitivity and SpecificityTandem Mass SpectrometryPeptide FragmentsSaccharomyces cerevisiae Proteins

Identifiers

PMID23007965
PMCPMC3515694

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.