ArticleAge (Dordrecht, Netherlands)2013
Age-related differences in corticospinal excitability during a choice reaction time task.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Inhibitory control deficits in borderline personality disorder: a meta-analysis of stop-signal and Go/No-Go tasks.Psychological medicine · 2025Pooled it
- Age-Related Changes in the Plasticity of Neural Networks Assessed by Transcranial Magnetic Stimulation With Electromyography: A Systematic Review and Meta-Analysis.Frontiers in cellular neuroscience · 2019Pooled it
- A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Pooled it
- Characterising resting motor threshold in depressed individuals across life span: a large retrospective study.BMC psychiatry · 2025Article
- γ-Aminobutyric acids (GABA) and serum GABA/AABA (G/A) ratio as potential biomarkers of physical performance and aging.Scientific reports · 2023Article
- Novel 3-D action video game mechanics reveal differentiable cognitive constructs in young players, but not in old.Scientific reports · 2022Article
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- TDCS effects on pointing task learning in young and old adults.Scientific reports · 2021Article
- Alterations of hand sensorimotor function and cortical motor representations over the adult lifespan.Aging · 2020Article
- Task-related measures of short-interval intracortical inhibition and GABA levels in healthy young and older adults: A multimodal TMS-MRS study.NeuroImage · 2020Article
- Induced Suppression of the Left Dorsolateral Prefrontal Cortex Favorably Changes Interhemispheric Communication During Bimanual Coordination in Older Adults-A Neuronavigated rTMS Study.Frontiers in aging neuroscience · 2020Article
- Motor Skill Learning-Induced Functional Plasticity in the Primary Somatosensory Cortex: A Comparison Between Young and Older Adults.Frontiers in aging neuroscience · 2020Article
- Aging and GABA.Aging · 2018Article
- Article
- Nucleus accumbens and caudate atrophy predicts longer action selection times in young and old adults.Human brain mapping · 2016Article
- Effect of Aging on Motor Inhibition during Action Preparation under Sensory Conflict.Frontiers in aging neuroscience · 2016Article
- Switching between hands in a serial reaction time task: a comparison between young and old adults.Frontiers in aging neuroscience · 2015Article
- Increased reaction times and reduced response preparation already starts at middle age.Frontiers in aging neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related declines in central processing may affect corticospinal (CS) excitability that underlies the emergence of voluntary responses to external stimuli. We used single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex to explore the evolution of CS excitability in 14 young and ten elderly healthy right-handed participants. Motor-evoked potentials (MEPs) were elicited in the right or left first dorsal interosseus (FDI) during the preparatory and premotor periods of a choice reaction time (CRT) task, which required selection of left or right index finger responses. Both age groups showed significant suppression of CS excitability in the preparatory period. However, suppression was generally less pronounced in older than in young adults. Moreover, our data indicated that a reduced suppression in the right FDI during the preparatory period was associated with longer reaction times (RTs) in older adults only. In the premotor period, both age groups demonstrated comparable facilitation levels towards movement onset. Our findings indicate that increased RTs among older individuals could be directly associated with declines in preparatory processes.
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