ArticleBiological research for nursing2012
Stress and gene expression of individuals with chronic abdominal pain.
Article in Biological research for nursing, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Eating Behavior, Stress, and Adiposity: Discordance Between Perception and Physiology.Biological research for nursing · 2018Article
- Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress.BBA clinical · 2017Article
- Inflammatory genes and psychological factors predict induced shoulder pain phenotype.Medicine and science in sports and exercise · 2014Article
- Anti-Müllerian Hormone Levels and Urinary Cortisol in Women With Chronic Abdominal Pain.Journal of obstetric, gynecologic, and neonatal nursing : JOGNNArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundResearch examining the role of stress in gastrointestinal (GI) symptoms such as chronic abdominal pain (CAP) is controversial. The purpose of this study was to examine the expression of genes involved in metabolic stress and toxicity in men and women with high and low levels of perceived stress with and without CAP.
methodsData and samples were collected and the expression of genes involved in metabolic stress and toxicity was analyzed in 26 individuals who had consented to participate in a natural history protocol. Subjects completed the 10-item Perceived Stress scale (PSS). Fasting participants' peripheral whole blood was collected for proteomic and genomic studies. Polymerase chain reaction (PCR) array was used to analyze the expression of 84 key genes involved in human stress and toxicity plus 5 housekeeping genes. Plasma interleukin-1 alpha (IL-1α) protein was quantified via enzyme-linked immunosorbent assay (ELISA).
resultsInterleukin-1 alpha gene (IL1A) was upregulated in females with high stress versus females with low stress by 2.58-fold (95% CI [0.88, 4.28]). IL1A was upregulated in participants with high stress and CAP versus those with low stress and CAP by 3.47-fold (95% CI [1.14, 5.80]).
conclusionsAn upregulation of the gene coding the pro-inflammatory cytokine IL-1α suggests that the mechanism behind stress-related changes in GI symptoms is pro-inflammatory in nature. The results of this study contribute to the knowledge of the mechanism behind stress-related CAP symptoms and gender differences associated with these disorders.
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