ReviewCellular and molecular life sciences : CMLS2013
Robustness of signal transduction pathways.
Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Metabolic robustness is an emergent property of hierarchical network organization in yeast.mSystems · 2026Article
- Opposing insulin signals underlie the same developmental switch across hemipteran insects.Science advances · 2026Article
- Design principles of ciliary signaling.Journal of cell science · 2025Review
- Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways.International journal of molecular sciences · 2024Review
- Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway.PLoS computational biology · 2024Article
- Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Optogenetic actuator - ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics.Molecular systems biology · 2022Article
- Exon Definition Facilitates Reliable Control of Alternative Splicing in the RON Proto-Oncogene.Biophysical journal · 2020Article
- Tunneling nanotubes mediate the expression of senescence markers in mesenchymal stem/stromal cell spheroids.Stem cells (Dayton, Ohio) · 2020Article
- Correlated receptor transport processes buffer single-cell heterogeneity.PLoS computational biology · 2017Article
- Dynamics robustness of cascading systems.PLoS computational biology · 2017Article
- Dynamics and robustness of the cardiac progenitor cell induced pluripotent stem cell network during cell phenotypes transition.IET systems biology · 2017Article
- Transient absolute robustness in stochastic biochemical networks.Journal of the Royal Society, Interface · 2016Article
- Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway.Computers & chemical engineering · 2014Article
- MAP kinase modules: the excursion model and the steps that count.Biophysical journal · 2014Review
- Data-derived modeling characterizes plasticity of MAPK signaling in melanoma.PLoS computational biology · 2014Article
- A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.PLoS computational biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal transduction pathways transduce information about the outside of the cell to the nucleus, regulating gene expression and cell fate. To reliably inform the cell about its surroundings, information transfer has to be robust against typical perturbation that a cell experiences. Robustness of several mammalian signaling pathways has been studied recently by quantitative experimentation and using mathematical modeling. Here, we review these studies, and describe the emerging concepts of robustness and the underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.