ArticleArchives of pediatrics & adolescent medicine2012
Obesity, metabolic syndrome, and insulin resistance in urban high school students of minority race/ethnicity.
Article in Archives of pediatrics & adolescent medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Population-Based Studies on the Epidemiology of Insulin Resistance in Children.Journal of diabetes research · 2015Pooled it
- The EPIC Kids Study: a randomized family-focused YMCA-based intervention to prevent type 2 diabetes in at-risk youth.BMC public health · 2015Trial
- Sex Differences in Diet and Physical Activity Behaviors Among Racial/Ethnic Minority Adolescents with High Metabolic Risk.Journal of racial and ethnic health disparities · 2025Article
- Responsive parental support buffers the link between chronic stress and cardiometabolic risk among adolescents.Brain, behavior, and immunity · 2024Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- The Relationship between Anthropometric Measurements and Vitamin D Levels and Insulin Resistance in Obese Children and Adolescents.Children (Basel, Switzerland) · 2022Article
- Impact of One-Year Dietary Education on Change in Selected Anthropometric and Biochemical Parameters in Children with Excess Body Weight.International journal of environmental research and public health · 2022Article
- Responsiveness on metabolic syndrome criteria and hepatic parameters after 12 weeks and 24 weeks of multidisciplinary intervention in overweight adolescents.Journal of endocrinological investigation · 2022Article
- Familial dietary intervention in children with excess body weight and its impact on eating habits, anthropometric and biochemical parameters.Frontiers in endocrinology · 2022Article
- Functional connectivity in central executive network protects youth against cardiometabolic risks linked with neighborhood violence.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pregnancy-Associated Hypertension and Offspring Cardiometabolic Health.Obstetrics and gynecology · 2018Observational
- Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity.Frontiers in psychiatry · 2018Article
- Asian Adolescents with Excess Weight are at Higher Risk for Insulin Resistance than Non-Asian Peers.Obesity (Silver Spring, Md.) · 2017Article
- Prevalence of Metabolic Syndrome and Its Individual Components Among Midwestern University Students.Journal of community health · 2017Article
- Niclosamide as an anti-obesity drug: an experimental study.Eating and weight disorders : EWD · 2017Article
- Obese Adolescents Show Reduced Cognitive Processing Speed Compared with Healthy Weight Peers.Childhood obesity (Print) · 2017Article
- Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?Inflammation · 2016Article
- Article
- Retinal vessel alterations and cerebral white matter microstructural damage in obese adolescents with metabolic syndrome.JAMA pediatrics · 2014Article
- Preliminary evidence of cognitive and brain abnormalities in uncomplicated adolescent obesity.Obesity (Silver Spring, Md.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine the point prevalences of metabolic syndrome (MetS) and its components among healthy weight, overweight, and obese inner-city public high school students, to compare the prevalences of MetS when using 2 different definitions (one with the impaired fasting glucose [IFG] level and the other with a homeostasis model assessment of insulin resistance [HOMA-IR] of 3.99 or higher to define the glucose regulation component), and to compare the degree to which HOMA-IR and fasting glucose level are associated with the other MetS components.
designCross-sectional analysis.
settingTwo New York City public high schools, from April 2008 through August 2011.
participantsConvenience sample of 1185 high school youth, comprising predominantly Hispanic and African American students from low-income households, participating in The Banishing Obesity and Diabetes in Youth Project, a medical screening and education program.
main outcome measuresPrevalences of the following individual MetS components: IFG threshold, HOMA-IR, hypertension, central adiposity, hypertriglyceridemia, and low high-density lipoprotein cholesterol. Rates of MetSIFG and MetSHOMA-IR were also assessed.
resultsMetSIFG and MetSHOMA-IR point prevalences were both 0.3% in the healthy weight group; they were 2.6% and 5.9%, respectively, in the overweight group and were 22.9% and 35.1%, respectively, in the obese group (P < .05 for both). An IFG threshold of 100 mg/dL or higher was found in 1.0% of participants, whereas a HOMA-IR of 3.99 or higher was found in 19.5% of participants.
conclusionsAn elevated HOMA-IR is much more sensitive than an IFG threshold in identifying adolescents with metabolic dysregulation. Using a HOMA-IR threshold of 3.99 identifies more youth with MetS than using an IFG threshold of 100 mg/dL. In addition to increasing the sensitivity of MetS detection, HOMA-IR has a much higher association with the other MetS components than the IFG threshold and may better reflect a unified underlying pathologic process useful to identify youth at risk for disease.
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Registered trials
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