ReviewWorld journal of urology2013
Upper urinary tract instillations in the treatment of urothelial carcinomas: a review of technical constraints and outcomes.
Review in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Oncologic outcomes of radical radiotherapy in frail patients with upper tract urothelial carcinoma.BJU international · 2026Article
- Hemophagocytic syndrome in A patient of upper urinary tract urothelial cancer after Bacillus Calmette-Guérin instillation: A case report.Urology case reports · 2024Article
- Future strategies to enhance kidney preservation in upper urinary tract urothelial carcinoma.Translational andrology and urology · 2020Review
- Management of Low-grade Upper Tract Urothelial Carcinoma: An Unmet Need.Reviews in urology · 2020Article
- Advances in the management of upper tract urothelial carcinoma: improved endoscopic management through better diagnostics.Therapeutic advances in urology · 2018Review
- Why are upper tract urothelial carcinoma two different diseases?Translational andrology and urology · 2016Review
- Upper tract urothelial carcinoma: a different disease entity in terms of management.ESMO open · 2016Review
- Upper urinary tract disease: what we know today and unmet needs.Translational andrology and urology · 2015Review
- Risk-adapted strategy for the kidney-sparing management of upper tract tumours.Nature reviews. Urology · 2015Review
- Endoscopic management of upper urinary tract urothelial carcinoma.Korean journal of urology · 2013Article
- Is ureteral stent an effective way to deliver drugs such as bacillus Calmette-Guérin to the upper urinary tract? An experimental study.Therapeutic advances in urologyArticle
- Which is best method for instillation of topical therapy to the upper urinary tract? An in vivo porcine study to evaluate three delivery methods.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- The safety and efficacy of ultrasound versus fluoroscopic percutaneous nephrostomy: A prospective randomized study.Urology annalsArticle
- BCG-related renal granulomas managed conservatively: A case series.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe role of topical upper urinary tract instillation as adjuvant treatment after conservative management of urothelial carcinomas remains unclear. The aim of this article was to review available techniques and protocols proposed to treat urothelial carcinomas of the upper tract (UTUC).
methodsEvidence acquisition on UTUC topical instillations was performed by a Medline search using combinations of the following key words: urothelial carcinomas; upper urinary tract; renal pelvis; ureter; adjuvant therapy; recurrence; bacillus Calmette-Guérin (BCG); mitomycin C. A total of 36 publications were included in analysis.
resultsDifferent approaches have been reported for instillation of the upper tract (UT): percutaneous nephrostomy, retrograde catheterisation and vesico-ureteral reflux. Currently, BCG and mitomycin C are the most commonly agents used for topical treatment of UTUC. A role for BCG in the management of UT carcinoma in situ (CIS) has been demonstrated in retrospective studies, although a definitive efficacy of adjuvant topical therapy after endoscopic resection of Ta/T1 tumours has not yet been proven. No individual study has shown a statistical improvement in survival and recurrence rates.
conclusionCurrently BCG instillation should be considered as first-line treatment for UT CIS managed conservatively in carefully selected patients. The place for adjuvant topical instillation after ablation of Ta/T1 tumours is less evident and should be evaluated on an individual basis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.