ArticleThe Journal of cell biology2012
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- Spatiotemporal coordination of actin regulators generates invasive protrusions in cell-cell fusion.Nature cell biology · 2024Article
- Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene.Current biology : CB · 2024Article
- The cellular architecture and molecular determinants of the zebrafish fusogenic synapse.Developmental cell · 2022Article
- Inhibition of negative feedback for persistent epithelial cell-cell junction contraction by p21-activated kinase 3.Nature communications · 2022Article
- Review
- Review
- Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.Nature cell biology · 2020Article
- Suppression ofFrontiers in neuroscience · 2020Article
- Review
- The fusogenic synapse at a glance.Journal of cell science · 2019Review
- Ubiquitination and Long Non-coding RNAs Regulate Actin Cytoskeleton Regulators in Cancer Progression.International journal of molecular sciences · 2019Review
- Late-onset megaconial myopathy in mice lacking group I Paks.Skeletal muscle · 2019Article
- Myomaker and Myomerger Work Independently to Control Distinct Steps of Membrane Remodeling during Myoblast Fusion.Developmental cell · 2018Article
- Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion.Nature cell biology · 2018Article
- Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.Molecular and cellular biology · 2017Article
- Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis.Cold Spring Harbor perspectives in biology · 2017Review
- Filamin, a synaptic organizer ineLife · 2016Article
- A new level of plasticity: Drosophila smooth-like testes muscles compensate failure of myoblast fusion.Development (Cambridge, England) · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
The p21-activated kinases (PAKs) play essential roles in diverse cellular processes and are required for cell proliferation, apoptosis, polarity establishment, migration, and cell shape changes. Here, we have identified a novel function for the group I PAKs in cell-cell fusion. We show that the two Drosophila group I PAKs, DPak3 and DPak1, have partially redundant functions in myoblast fusion in vivo, with DPak3 playing a major role. DPak3 is enriched at the site of fusion colocalizing with the F-actin focus within a podosome-like structure (PLS), and promotes actin filament assembly during PLS invasion. Although the small GTPase Rac is involved in DPak3 activation and recruitment to the PLS, the kinase activity of DPak3 is required for effective PLS invasion. We propose a model whereby group I PAKs act downstream of Rac to organize the actin filaments within the PLS into a dense focus, which in turn promotes PLS invasion and fusion pore initiation during myoblast fusion.
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Registered trials
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