Evidence map›Paper›PMID 23007552›Full record

ArticlePlanta2013

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics.

Chad Brocker, Melpomene Vasiliou, Sarah Carpenter, Christopher Carpenter, Yucheng Zhang, Xiping Wang, Simeon O Kotchoni, Andrew J Wood, Hans-Hubert Kirch, David Kopečný and 2 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Planta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 173 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-wide analysis of the ALDH superfamily inFrontiers in plant science · 2026
    Article
  4. Article
  5. Article
  6. Journal of fungi (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The Aldehyde Dehydrogenase Superfamily inInternational journal of molecular sciences · 2025
    Article
  14. Identification of Aldehyde Dehydrogenase Gene Family inInternational journal of molecular sciences · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Transcriptomic and physiological responses ofFrontiers in plant science · 2024
    Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Chad BrockerDepartment of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Melpomene Vasiliou
Sarah Carpenter
Christopher Carpenter
Yucheng Zhang
Xiping Wang
Simeon O Kotchoni
Andrew J Wood
Hans-Hubert Kirch
David Kopečný
Daniel W Nebert
Vasilis Vasiliou
University of Colorado Anschutz Medical Campus · USNorthwest A&F University · CNPalacký University Olomouc · CZRutgers, The State University of New Jersey · USSouthern Illinois University Carbondale · USUniversity of Bonn · DEUniversity of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Role and Molecular Mechanisms of Corneal Aldehyde DehydrogenaseR01EY011490 · NEI · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2004 to 2013
$4.0M
Novel Role of Corneal Crystallins as Modulators of Cell Growth and TransparencyR01EY017963 · NEI · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2007 to 2019
$3.7M
Role of Mitochondrial Aldehyde Dehydrogenases in Ethanol Metabolism and ToxicityR21AA017754 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI VASILIOU, VASILIS · 2009 to 2010
$411k
Role of ALDH7A1 in Ethanol-Induced Oxidative DamageF31AA018248 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI BROCKER, CHAD NICHOLAS · 2010 to 2011
$52k
NEI NIH HHS R01 EY011490NEI NIH HHS R01 EY017963NEI NIH HHS R01 EY17963NIAAA NIH HHS F31 AA018248NIAAA NIH HHS R21 AA017754NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

In recent years, there has been a significant increase in the number of completely sequenced plant genomes. The comparison of fully sequenced genomes allows for identification of new gene family members, as well as comprehensive analysis of gene family evolution. The aldehyde dehydrogenase (ALDH) gene superfamily comprises a group of enzymes involved in the NAD(+)- or NADP(+)-dependent conversion of various aldehydes to their corresponding carboxylic acids. ALDH enzymes are involved in processing many aldehydes that serve as biogenic intermediates in a wide range of metabolic pathways. In addition, many of these enzymes function as 'aldehyde scavengers' by removing reactive aldehydes generated during the oxidative degradation of lipid membranes, also known as lipid peroxidation. Plants and animals share many ALDH families, and many genes are highly conserved between these two evolutionarily distinct groups. Conversely, both plants and animals also contain unique ALDH genes and families. Herein we carried out genome-wide identification of ALDH genes in a number of plant species-including Arabidopsis thaliana (thale crest), Chlamydomonas reinhardtii (unicellular algae), Oryza sativa (rice), Physcomitrella patens (moss), Vitis vinifera (grapevine) and Zea mays (maize). These data were then combined with previous analysis of Populus trichocarpa (poplar tree), Selaginella moellindorffii (gemmiferous spikemoss), Sorghum bicolor (sorghum) and Volvox carteri (colonial algae) for a comprehensive evolutionary comparison of the plant ALDH superfamily. As a result, newly identified genes can be more easily analyzed and gene names can be assigned according to current nomenclature guidelines; our goal is to clarify previously confusing and conflicting names and classifications that might confound results and prevent accurate comparisons between studies.

Indexed as

Multigene FamilyAldehyde DehydrogenaseAldehydesAnimalsArabidopsisBryopsidaChlamydomonas reinhardtiiChromosome MappingChromosomes, PlantEvolution, MolecularGenome, PlantGenomicsOryzaPlant ProteinsPlantsPopulusAldehyde DehydrogenaseAldehydesPlant Proteins

Identifiers

PMID23007552
PMCPMC3536936
OpenAlexW2063022102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.