ArticleSocial psychiatry and psychiatric epidemiology2013
Description of long-term polypharmacy among schizophrenia outpatients.
Article in Social psychiatry and psychiatric epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Socioenvironmental determinants of polypharmacy in mental health disorders: a systematic review.BMC public health · 2026Pooled it
- Prevalence and factors associated with polypharmacy: a systematic review and Meta-analysis.BMC geriatrics · 2022Pooled it
- Meta-analysis of cognitive functioning in patients with psychotic disorders and obsessive-compulsive symptoms.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Understanding Antipsychotic Polypharmacy in Bipolar Disorder: The Role of Long-Acting Injectable Antipsychotics in a Naturalistic Inpatient Setting.The Psychiatric quarterly · 2026Article
- Antipsychotic prescription patterns among schizophrenia patients in Guangdong Province, China's 686 program: A retrospective study.Medicine · 2024Article
- Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients.International journal of circumpolar health · 2023Article
- Article
- Case report: Successful administration of cariprazine in a young, severely ill patient with recurrent relapses of schizophrenia and persistent negative symptoms.Frontiers in psychiatry · 2023Article
- Antipsychotic polypharmacy in adult patients diagnosed with schizophrenia: A retrospective study.Experimental and therapeutic medicine · 2021Article
- Polypharmacy trajectories among older women with and without dementia: A longitudinal cohort study.Exploratory research in clinical and social pharmacy · 2021Article
- Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia.Scientific reports · 2021Observational
- The More, the Merrier…? Antipsychotic Polypharmacy Treatment Strategies in Schizophrenia From a Pharmacology Perspective.Frontiers in psychiatry · 2021Article
- Diagnose, indicate, and treat severe mental illness (DITSMI) as appropriate care: A three-year follow-up study in long-term residential psychiatric patients on the effects of re-diagnosis on medication prescription, patient functioning, and hospital bed utilization.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Prescription practices in the treatment of agitation in newly hospitalized Chinese schizophrenia patients: data from a non-interventional naturalistic study.BMC psychiatry · 2019Observational
- Drug exposure in register-based research-An expert-opinion based evaluation of methods.PloS one · 2017Article
- Do doctors agree on doses of antipsychotic medications?Therapeutic advances in psychopharmacology · 2016Article
- Predictors of long-term (≥6months) antipsychotic polypharmacy prescribing in secondary mental healthcare.Schizophrenia research · 2016Article
- Diabetes and Schizophrenia.Current diabetes reports · 2016Review
- Extracting antipsychotic polypharmacy data from electronic health records: developing and evaluating a novel process.BMC psychiatry · 2015Article
- Prescription patterns for patients with schizophrenia in Korea: a focus on antipsychotic polypharmacy.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis large nationwide study describes the prevalence and predictors of long-term antipsychotic polypharmacy among patients with schizophrenia.
methodsA register-based longitudinal study of all people in Finland, who had at least one hospitalization due to schizophrenia during the years 2000-2007 and who were alive on March 1, 2007. Entry to the cohort was defined from the first hospitalization for schizophrenia during the years 2000-2007, and the date of assessment of antipsychotic polypharmacy was March 1, 2007. We studied separately chronic (N = 8,037) and recent onset (N = 8,046) schizophrenia patients. Antipsychotic polypharmacy was defined as overlapping of two or more filled prescriptions of antipsychotics for over 60 days.
resultsIn a total 16,083 patients with schizophrenia the prevalence of antipsychotic polypharmacy was 46.2 % (N = 7,436, mean age 47.5 years, male 55 %). The longer the duration of schizophrenia, the more common the antipsychotic polypharmacy. Long index hospitalization and being male significantly associated with antipsychotic polypharmacy among all schizophrenia patients. Especially, in chronic schizophrenia patients, the previous use of benzodiazepine like agents was associated with antipsychotic polypharmacy, but the use of antidepressants associated with less frequent antipsychotic polypharmacy.
conclusionsAntipsychotic polypharmacy was widely prevalent among patients with schizophrenia and it was associated with long hospitalizations and long duration of illness. Benzodiazepine use was associated with increased risk and antidepressant use with decreased risk of antipsychotic polypharmacy when the effect of other clinical and socioeconomic factors was adjusted. Research is needed of risks and benefits of antipsychotic polypharmacy and augmentation of antipsychotic with other psychoactive drugs.
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