ArticleCardiovascular ultrasound2012
Atrial fibrillation in aortic stenosis--echocardiographic assessment and prognostic importance.
Article in Cardiovascular ultrasound, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Effect of direct oral anticoagulants in patients with atrial fibrillation with mitral or aortic stenosis: A review.Frontiers in cardiovascular medicine · 2022Pooled it
- Biatrial Inflammatory and Fibrotic Remodeling in Severe Aortic Stenosis Compared with CABG Controls.Metabolites · 2026Article
- Differences in cardiac output of patients undergoing trans-catheter aortic valve implantation according to their underlying rhythm.World journal of cardiology · 2026Article
- Clinical, Echocardiographic, and Socioeconomic Predictors of Progression and Outcomes in Patients With Moderate Aortic Stenosis.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Ventricular Arrhythmias in Severe Aortic Stenosis Prior to Aortic Valve Replacement: A Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Echocardiographic assessment of atrial, ventricular, and valvular function in patients with atrial fibrillation-an expert proposal by the german working group of cardiovascular ultrasound.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- The impact of atrial fibrillation on prognosis in aortic stenosis.European heart journal. Quality of care & clinical outcomes · 2023Article
- Impact of atrial fibrillation on outcomes in asymptomatic severe aortic stenosis: a propensity-matched analysis.Frontiers in cardiovascular medicine · 2023Article
- Serum miR-222 is independently associated with atrial fibrillation in patients with degenerative valvular heart disease.BMC cardiovascular disorders · 2021Article
- Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis.BMC cardiovascular disorders · 2020Article
- Atrial fibrillation is not an independent predictor of outcome in patients with aortic stenosis.Heart (British Cardiac Society) · 2020Article
- Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study.PloS one · 2020Observational
- Delayed Time to Peak Velocity Is Useful for Detecting Severe Aortic Stenosis.Journal of the American Heart Association · 2016Article
- Pathophysiology and management of multivalvular disease.Nature reviews. Cardiology · 2016Review
- Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation.PeerJ · 2016Article
- Orthostatic stress echocardiography as a useful test to measure variability of transvalvular pressure gradients in aortic stenosis.Cardiovascular ultrasound · 2013Article
- Potential Diagnostic and Prognostic Values of Left Atrial Strain in Valvular Heart Disease.Journal of cardiovascular echographyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AFib) exists more frequently in patients with aortic stenosis (AS) than in patients without, and AFib may be a sign of progressive deterioration of AS. Echocardiographic assessment of AS in sinus rhythm is well documented, however, little is known about AFib in AS since such patients often are excluded from clinical echocardiographic trials.
aimThe purpose of this study was to assess the prognostic importance of AFib in AS.
methodsThe study was designed as a single-center case-control study. Patients with AS and AFib were enrolled as cases (n = 103) and subsequently matched to controls (103 patients with AS but sinus rhythm). Cases and controls were matched according to age, gender and severity of AS. Primary outcome was all cause mortality and follow-up was 100% complete.
resultsCompared to controls the group with AFib had lower mean ejection fraction (42% vs. 49%; p < 0.001) and stroke volume (47 mL vs. 55 mL; p = 0.004), but higher heart rate (81 bpm vs. 68 bpm; p < 0.001) and no significant difference with regard to cardiac output (3.8 L vs. 4.0 L; p = 0.29). Accordingly, aortic jet velocity and gradients were significantly lower in AFib compared to controls but there were no differences (p = 0.38) in aortic valve area calculated by the continuity equation. During a median follow-up of 2.3 years (IQR: 1.2-3.6), 70 (34%) patients with AS died: 42 patients with AFib and 28 patients with sinus rhythm (p < 0.02). After adjusting for echocardiographic significant differences, AFib remained an independent predictor of mortality (HR 2.72 (95% CI: 1.12-6.61), p < 0.03). There was no significant interaction (p = 0.62) between AFib and AS on the risk of mortality, indicating that AFib predicted bad outcome regardless of the severity of AS.
conclusionsAFib is an independent risk factor in patients with AS and the prognostic impact of AFib seems to be the same despite the severity of AS.
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Registered trials
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