Evidence map›Paper›PMID 23006613›Full record

ArticleRespiratory research2012

Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial.

Miek Hornikx, Hans Van Remoortel, An Lehouck, Chantal Mathieu, Karen Maes, Ghislaine Gayan-Ramirez, Marc Decramer, Thierry Troosters, Wim Janssens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 9 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 9 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  5. Vitamin D for the management of chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2024
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  8. Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2015
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  17. Vitamin DEuropean journal of nutrition · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Miek HornikxRespiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium.
Hans Van Remoortel
An Lehouck
Chantal Mathieu
Karen Maes
Ghislaine Gayan-Ramirez
Marc Decramer
Thierry Troosters
Wim Janssens
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. MATERIAL AND

methodsThis study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation.

resultsVitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050).

conclusionHigh dose vitamin D supplementation during rehabilitation may have mild additional benefits to training.

Indexed as

Dietary SupplementsAgedDose-Response Relationship, DrugDouble-Blind MethodExercise ToleranceFemaleForced Expiratory VolumeHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthOxygen ConsumptionPulmonary Disease, Chronic ObstructiveTreatment OutcomeVital CapacityVitamin D

Identifiers

PMID23006613
PMCPMC3493348
OpenAlexW2111901047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.