Evidence map›Paper›PMID 23006339›Full record

ArticleClinical nephrology2013

Minimal change disease in graft versus host disease: a podocyte response to the graft?

Janna Huskey, Chris Rivard, Han Myint, Scott Lucia, Maxwell Smith, Michiko Shimada, Takuji Ishimoto, Carlos Araya, Eduardo H Garin, Richard J Johnson

Open access · greenAbstract readCase Reports
In one paragraph

Article in Clinical nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Janna Huskey
Chris Rivard
Han Myint
Scott Lucia
Maxwell Smith
Michiko Shimada
Takuji Ishimoto
Carlos Araya
Eduardo H Garin
Richard J Johnson
University of Florida · USMayo Clinic in Florida · USPalmetto Hematology Oncology · USUniversity of Colorado Denver · US

Funding

CD80 Expression on Podocytes and the Pathogenesis of Minimal Change DiseaseR01DK080764 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GARIN, EDUARDO HUMBERTO, JOHNSON, RICHARD JOSEPH · 2011 to 2013
$546k
NIDDK NIH HHS DK-80764
6 · The paper itself

Abstract

Nephrotic syndrome is a rare complication of hematopoietic cell transplantation. It has been suggested that nephrotic syndrome may represent a limited form of graft-versus-host disease although the pathological link between these two entities remains unclear. In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy. Urinary CD80 was markedly elevated during active disease and disappeared following corticosteroid-induced remission. We hypothesize that alloreactive donor T cells target the kidney and induce podocyte expression of CD80 that results in proteinuria from limited 'graft versus host' disease.

Indexed as

B7-1 AntigenFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansMiddle AgedNephrosis, LipoidPodocytesProteinuriaTransplantation, HomologousB7-1 Antigen

Identifiers

PMID23006339
PMCPMC4504137
OpenAlexW2332017361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.