ArticleAddictive behaviors2013
Adolescents' fMRI activation to a response inhibition task predicts future substance use.
Article in Addictive behaviors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 146 citations in OpenAlex.
- Longitudinal changes in network engagement during cognitive control in cocaine use disorder.Drug and alcohol dependence · 2021Trial
- Cognitive Process Models Reveal Meaningful Brain-Behavior Associations in the Adolescent Brain Cognitive Development Study Stop-signal Task.Journal of cognitive neuroscience · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective.Frontiers in psychiatry · 2025Article
- Effects of Stimulant Treatment on Changes in Brain Activation During Reward Notifications in Drug Naïve Youth With ADHD.Journal of attention disorders · 2024Article
- Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.Nature communications · 2023Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task.Human brain mapping · 2023Article
- A Comparison of Task-Based and Questionnaire Assessments of Executive Control Aspects in Relation to Adolescent Marijuana Initiation.Cannabis (Albuquerque, N.M.) · 2023Article
- A cognitive process modeling framework for the ABCD study stop-signal task.Developmental cognitive neuroscience · 2023Article
- Neurophysiology of movement inhibition during full body reaching.Scientific reports · 2022Article
- The mediating role of impulsivity in the associations between child maltreatment types and past month substance use.Child abuse & neglect · 2022Article
- Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence.Neuroscience and biobehavioral reviews · 2022Review
- Neurophysiological correlates of interference control and response inhibition processes in children and adolescents engaging in open- and closed-skill sports.Journal of sport and health science · 2022Article
- Examining Inhibitory Affective Processing Within the Rostral Anterior Cingulate Cortex Among Abstinent Cannabis-Using Adolescents and Young Adults.Frontiers in psychiatry · 2022Article
- Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies.Developmental cognitive neuroscience · 2021Review
- Subtypes of inhibitory and reward activation associated with substance use variation in adolescence: A latent profile analysis of brain imaging data.Cognitive, affective & behavioral neuroscience · 2021Article
- Evidence accumulation and associated error-related brain activity as computationally-informed prospective predictors of substance use in emerging adulthood.Psychopharmacology · 2021Article
- Predicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2021Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeficient behavioral regulation may be a risk factor for substance use disorders in adolescents. Abnormalities in brain regions critical to cognitive control have been linked to more intense and problematic future substance use (e.g., Durazzo, Gazdzinski, Mon, & Meyerhoff, 2010; Falk, Berkman, Whalen, & Lieberman, 2011; Paulus, Tapert, & Schuckit, 2005). The goal of this study was to examine the degree to which brain response to an inhibition task measured in mid-adolescence can predict substance use 18 months later.
methodAdolescents aged 16-19 (N=80) performed a go/no-go response inhibition task during fMRI at project baseline, and were followed 18 months later with a detailed interview on substance use and dependence symptoms. Participants were 39 high frequency users and 41 demographically similar low frequency users (458 versus 2 average lifetime drug use occasions at baseline, respectively).
resultsAcross all subjects, no-go trials produced significant increases in neural response in the ventromedial prefrontal cortex and a region including the left angular and supramarginal gyri (p(FWE)<.01, cluster threshold ≥ 30 voxels). Less ventromedial prefrontal activation but more left angular gyrus activation predicted higher levels of substance use and dependence symptoms in the following 18 months, particularly for those who were high frequency users in mid-adolescence (p<.05).
conclusionsThese findings are consistent with studies showing that impairments in cognitive control have strong associations with substance use. We found a predictive relationship between atypical activation patterns at baseline and substance use behavior 18 months later, particularly among adolescents with histories of previous heavy use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.