Evidence map›Paper›PMID 23006216›Full record

ArticleMetabolism: clinical and experimental2013

Effect of low dose mineralocorticoid receptor antagonist eplerenone on glucose and lipid metabolism in healthy adult males.

Alexander W Krug, Lissy Stelzner, Ajaykumar D Rao, Andrew H Lichtman, Gordon H Williams, Gail K Adler

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01786551 (Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01786551 nacompletednot on this map

Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults

TypeinterventionalSponsorBrigham and Women's HospitalRan2010 to 2013Enrolled16ConditionsSystemic Proinflammatory StateArmsEplerenone
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Mineralocorticoid receptors in the pathogenesis of insulin resistance and related disorders: from basic studies to clinical disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alexander W KrugBrigham and Women's Hospital, Harvard Medical School, Division of Endocrinology, Diabetes, and Hypertension, Boston, USA. alexander.krug@t-online.de
Lissy Stelzner
Ajaykumar D Rao
Andrew H Lichtman
Gordon H Williams
Gail K Adler
Brigham and Women's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Striatin, Aldosterone and HypertensionR01HL114765 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARZA, AMANDA ELIZABETH, WILLIAMS, GORDON H · 2013 to 2017
$4.3M
Regulation of T Cell Responses in AtherosclerosisR01HL087282 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LICHTMAN, ANDREW H · 2007 to 2015
$4.0M
Role of Mineralocorticoid Receptor in Diabetic Cardiovascular DiseaseR01HL087060 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 2008 to 2011
$2.5M
Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring ProgamK24HL103845 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 2011 to 2021
$1.6M
NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1 RR025758-01NHLBI NIH HHS K24 HL103845NHLBI NIH HHS K24HL-103845NHLBI NIH HHS R01 HL087060NHLBI NIH HHS R01HL 087060NHLBI NIH HHS R01 HL087282NHLBI NIH HHS R01 HL114765NHLBI NIH HHS T32 HL007609
6 · The paper itself

Abstract

unlabelledMineralocorticoid Receptor (MR) activation is involved in blood pressure regulation and the pathogenesis of cardiovascular diseases, such as cardiac fibrosis, vascular inflammation and arterial aging. Recent investigations suggest a role for MR activation in metabolic dysregulation.

objectiveTo test the effect of MR blockade on basal and postprandial glucose and lipid levels after a meal high in fat and glucose in healthy males. SUBJECTS AND

methodsA prospective, self-controlled study was performed in 13 healthy adult males aged 18-45years. Blood was drawn before, 2h, and 4h after a high fat/high glucose meal (50g fat, 75g glucose), followed by low-dose eplerenone treatment (50mg daily) for 14days. Subjects returned for a second high fat/high glucose meal after the medication period. Basal and postprandial blood glucose and lipid levels were compared before and after eplerenone treatment.

resultsEplerenone treatment affected neither basal nor postprandial glucose and lipid levels in our study population.

conclusionOur results suggest that low-dose, non-blood pressure-affecting, MR blockade does not alter postprandial lipid and glucose homeostasis in healthy adult subjects.

Indexed as

AdolescentAdultBlood GlucoseBlood PressureCholesterolEplerenoneGlucoseHumansInsulinInsulin ResistanceLipid MetabolismMaleMiddle AgedMineralocorticoid Receptor AntagonistsPostprandial PeriodProspective StudiesBlood GlucoseCholesterolEplerenoneGlucoseInsulinMineralocorticoid Receptor AntagonistsReceptors, MineralocorticoidSpironolactone

Identifiers

PMID23006216
PMCPMC4403630
OpenAlexW2064214501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.